Year 2018 / Volume 110 / Number 7
Original
EUS-FNA cytological material from pancreatic lesions: the expression of cathepsins and its predictive value of malignancy

446-450

DOI: 10.17235/reed.2018.4200/2016

Manuela Roger, Juan Martínez, Gloria Peiró, Jose Ramón Aparicio, Francisco Ruiz, Luís Compañy, Juan Antonio Casellas,

Abstract
Aims: To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC). Methods: We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples. Results: Seventeen FNA were performed. All cytological material was from PDAC. Expression of cathepsins was predominantly low (B 65%, L 23%, S 76%, and H 41%). We found no correlation between the expression levels and the extension of the neoplasm. Conclusion: Expression of cathepsins in the cytological material of PDAC is diverse but still poor to be useful in the pre-operative diagnosis. There is no correlation between the expression levels of cathepsins and the extension of the PDAC
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Roger M, Martínez J, Peiró G, Aparicio J, Ruiz F, Compañy L, et all. EUS-FNA cytological material from pancreatic lesions: the expression of cathepsins and its predictive value of malignancy. 4200/2016


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Publication history

Received: 11/01/2016

Accepted: 11/02/2018

Online First: 12/06/2018

Published: 02/07/2018

Article revision time: 729 days

Article Online First time: 883 days

Article editing time: 903 days


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