Year 2023 / Volume 115 / Number 1
Letter
Primary hepatic neuroendocrine carcinoma with subsequent cerebral and spinal metastases

45-46

DOI: 10.17235/reed.2022.8967/2022

Qingyong Cao, Jun Li,

Abstract
A 72-year-old man was referred to us for evaluation of asymptomatic masses in the liver that had been detected on ultrasonography performed during a physical screening. The level of neuron-specific enolase was elevated (56.97 ng/mL; normal level, 15.7-17.0 ng/mL). Other tumor markers were normal, including alpha fetoprotein, carcinoembryonic antigen and cancer antigen 199. No tumor was found through chest CT scan, gastroscopy and colonoscopy. Abdominal MR demonstrated multiple masses with irregular central necrosis, which appeared as marked hyperintensity on T2WI. Most lesions showed rim-like enhancement at portal venous phase. Pathological examination of tissue obtained by means of percutaneous biopsy indicated that the tumor was composed of small cells which were arranged in nests and trabeculae, the nuclei were round with little cytoplasm, and nuclear division was present (hematoxylin-eosin stain.
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References
1.Modlin IM, Oberg K, Chung DC, et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 2008;9:61-72.
2.Li RK, Zhao J, Rao SX, Chen CZ, Zeng MS, Qiang JW. Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. Abdom Imaging. 2013;38:1269-1276.
3.Wang LM, An SL, Wu JX. Diagnosis and therapy of primary hepatic neuroendocrine carcinoma: clinical analysis of 10 cases. Asian Pac J Cancer Prev. 2014;15:2541-2546.
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Cao Q, Li J. Primary hepatic neuroendocrine carcinoma with subsequent cerebral and spinal metastases. 8967/2022


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Publication history

Received: 28/05/2022

Accepted: 02/06/2022

Online First: 15/06/2022

Published: 12/01/2023

Article Online First time: 18 days

Article editing time: 229 days


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