Year 2021 / Volume 113 / Number 11
Letter
Mixed adenoneuroendocrine carcinoma of the colon — a complex and unique clinical duality

796-797

DOI: 10.17235/reed.2021.7873/2021

Beatriz Arencibia Pérez, Julio José Delgado Sánchez, Joaquín Marchena Gómez,

Abstract
In relation to the article “A case of mixed adenoneuroendocrine tumor of the colon”, we would like to contribute a new case of this exceptional and biphasic clinical entity — the MANEC (mixed adenoneuroendocrine carcinoma). These tumors represent a mix of pathological components, are highly aggressive, and affect the gastrointestinal and pancreatobiliary tract. They are characterized by the dual presence of glandular and neuroendocrine epithelial elements, where each component represents at least 30 % of the tumor.
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References
Silva JR da, Pinho RT, Furtado A, et al. A case of a mixed adenoneuroendocrine tumor of the colon. Rev Espanola Enfermedades Dig Organo Of Soc Espanola Patol Dig 2017;109:673. DOI: 10.17235/reed.2017.5008/2017
2. Rindi G, Klöppel G, Couvelard A, et al. TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch Int J Pathol 2007;451:757-62. DOI: 10.1007/s00428-007-0452-1
3. Qiu S, Pellino G, Warren OJ, et al. Mixed adenoneuroendocrine carcinoma of the colon and rectum. Acta Chir Belg 2018;118:273-7. DOI: 10.1080/00015458.2018.1482697
4. Minaya-Bravo AM, Garcia Mahillo JC, Mendoza Moreno F, et al. Large cell neuroendocrine - Adenocarcinona mixed tumour of colon: Collision tumour with peculiar behaviour. What do we know about these tumours? Ann Med Surg 2015;4:399-403. DOI: 10.1016/j.amsu.2015.10.004
5. Gurzu S, Fetyko A, Bara T, et al. Gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC): An immunohistochemistry study of 13 microsatellite stable cases. Pathol Res Pract 2019;215:152697. DOI: 10.1016/j.prp.2019.152697
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Arencibia Pérez B, Delgado Sánchez J, Marchena Gómez J. Mixed adenoneuroendocrine carcinoma of the colon — a complex and unique clinical duality. 7873/2021


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Publication history

Received: 07/02/2021

Accepted: 29/05/2021

Online First: 22/06/2021

Published: 05/11/2021

Article revision time: 109 days

Article Online First time: 135 days

Article editing time: 271 days


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