Year 2024 / Volume 116 / Number 6
Letter
Multiple neuroendocrine tumors in the stomach, duodenum and pancreas of a MEN1 patient

339-341

DOI: 10.17235/reed.2023.9756/2023

Sihui Wang, Wenjia Zhang, Mengyue Xu, Min Xia,

Abstract
Gastrinoma, a common type of GEP-NENs, is often sporadic, rarely manifested as multiple endocrine neoplasia type 1 (MEN1). We described a rare case of MEN1-related gastrinomas in the stomach, duodenum and pancreas along with lymph node metastases. The female patient had a long history of recurrent abdominal pain and diarrhea. G1 neuroendocrine tumors were diagnosed by endoscopic biopsy in the pylorus, duodenal bulb and the neck of the pancreas successively. Her symptoms lessened and serum gastrin level decreased after surgery. This case will help us learn more about MEN1-associated patients who are confirmed with multiple neuroendocrine tumors.
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References
1. Fan JH, Zhang YQ, Shi SS, et al. A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china. Oncotarget 2017; 8(42):708.
2. Expert Committee on Neuroendocrine Neoplasms, Chinese Society of Clinical Oncology. Chinese expert consensus on gastroenteropancreatic neuroendocrine neoplasms (2022 edition). Chin J Oncol 2022; 44(12): 1305-1329.
3. Shan MH, Goldner WS, Benson AB, et al. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2021; 19(7): 839-68.
4. Al-salameh A, Casiot G, Calender A, et al. Clinical aspects of multiple endocrine neoplasia type 1. Nat Rev Endocrinol 2021; 17(4): 207-24.
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Wang S, Zhang W, Xu M, Xia M. Multiple neuroendocrine tumors in the stomach, duodenum and pancreas of a MEN1 patient. 9756/2023


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Publication history

Received: 30/05/2023

Accepted: 05/06/2023

Online First: 22/06/2023

Published: 04/06/2024

Article Online First time: 23 days

Article editing time: 371 days


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