Year 2025 / Volume 117 / Number 3
Letter
Functional paraganglioma, an uncommon cause of seminoma metastasis, diagnostic and therapeutic management

163-164

DOI: 10.17235/reed.2024.10232/2023

Alberto García Picazo, José Sáez, Alba Aramburu, Xavier Centeno, Cleofé Romagosa, Alberto Díez-Caballero Alonso,

Abstract
We report a 62-year-old male, with history of uncontrolled hypertension (3 drugs) in who, it was found an incidentally left retroperitoneal hypervascular tumor (5.7 x 3.5 cm) in the CT. It was demonstrated contact between tumor and left renal artery and ureter, without regional lymphadenopathy. The patient was asymptomatic, but had increased of norepinephrine (1141.1 pg/mL), epinephrine (93.3 pg/mL) and serotonin blood levels (264.1 g/L). The MRI confirm the tumor, with serotonin affinity in the 68Galium-Edotreotide PET/CT (DOTATATE) but not in the MIBG/Scan. Therefore, a paraganglioma was the suspected diagnosis. Tumor board recommended excision, due to the risk of being a functional paraganglioma. The tumor was resected through laparoscopic approach after alpha-beta-adrenergic blockade. Postoperatively, hypertension and norepinephrine blood levels were normalized. The histological report surprisingly showed a Seminoma (positivity for PLAP, OCT ¾, c-kit, MDM2) and the surgical margins were free.
New comment
Comments
No comments for this article
References
1. Rosenblum RC, Atlan K, Diment J, Mazeh H, Afek S, Rotman-Pikielny P, et al. A retroperitoneal seminoma with entrapped nerve ganglion masquerading as a paraganglioma. AACE Clin Case Rep. 2019;5(5):e321-e325.
2. Scali EP, Chandler TM, Heffernan EJ, Coyle J, Harris AC, Chang SD. Primary retroperitoneal masses: what is the differential diagnosis? Abdom Imaging. 2015;40(6):1887-1903.
3. Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, et al. Endocrine Society. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(6):1915-1942.
4. Bozkurt MF, Virgolini I, Balogova S, Beheshti M, Rubello D, Decristoforo C, et al. Guideline for PET/CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F-DOPA. Eur J Nucl Med Mol Imaging. 2017;44(9):1588-1601.
5. Janssen I, Blanchet EM, Adams K, Chen CC, Millo CM, Herscovitch P, et al. Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma. Clin Cancer Res. 2015;21(17):3888-3895.
Related articles

Letter

Malignant melanoma with liver, stomach, and duodenal metastasis

DOI: 10.17235/reed.2024.10851/2024

Letter

Intestinal metastases of colorectal cancer

DOI: 10.17235/reed.2024.10089/2023

Letter

Ileal metastasis from phyllodes breast tumor

DOI: 10.17235/reed.2023.9958/2023

Digestive Diseases Image

Enteroenteric intussusception caused by a small bowel metastatic cutaneous melanoma

DOI: 10.17235/reed.2023.9876/2023

Digestive Diseases Image

Germ cell tumor with duodenal involvement: a rare case of gastrointestinal bleeding

DOI: 10.17235/reed.2022.9327/2022

Letter

Vaginal lesion as first manifestation of colorectal disease

DOI: 10.17235/reed.2022.9270/2022

Digestive Diseases Image

Intrabiliary metastasis of colorectal adenocarcinoma: the SPY perspective

DOI: 10.17235/reed.2022.9202/2022

Digestive Diseases Image

The sentinel polyp: high-grade sarcoma revealed after colonic polypectomy

DOI: 10.17235/reed.2022.9093/2022

Digestive Diseases Image

Imaging findings of melanoma metastasis in the gallbladder

DOI: 10.17235/reed.2021.8176/2021

Digestive Diseases Image

Metastatic melanoma of the gallbladder: an uncommon finding

DOI: 10.17235/reed.2020.6407/2019

Digestive Diseases Image

Metastasis of dermatofibrosarcoma diagnosed by capsule endoscopy

DOI: 10.17235/reed.2018.4900/2017

Letter to the Editor

Chronic diarrhea, weight loss and heart failure. Features of the same disease?

DOI: 10.17235/reed.2017.4874/2017

Letter to the Editor

A rare cause of intestinal bleeding: duodenal metastasis from endometrial cancer

DOI: 10.17235/reed.2017.4822/2017

Letter to the Editor

Gangliocytic paraganglioma: an unusual cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2017.4808/2016

Digestive Diseases Image

Debut of an unusual liver cirrhosis

Letter to the Editor

Liver metastasis from colorectal cancer 12 years after liver transplantation

DOI: 10.17235/reed.2017.4507/2016

Letter to the Editor

Sister Mary Joseph’s nodule as initial pancreatic cancer manifestation

DOI: 10.17235/reed.2016.4479/2016

Case Report

Primary esophageal melanoma: report of a case

DOI: 10.17235/reed.2016.3908/2015

Letter to the Editor

Duodenal involvement by seminomatous tumors

DOI: 10.17235/reed.2015.3646/2014

Letter to the Editor

Leiomyosarcoma of the ascending colon: a rare tumor with poor prognosis

DOI: 10.17235/reed.2015.3606/2014

Citation tools
García Picazo A, Sáez J, Aramburu A, Centeno X, Romagosa C, Díez-Caballero Alonso A, et all. Functional paraganglioma, an uncommon cause of seminoma metastasis, diagnostic and therapeutic management. 10232/2023


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 66 visits.
This article has been downloaded 3 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 31/12/2023

Accepted: 12/01/2024

Online First: 29/01/2024

Published: 06/03/2025

Article Online First time: 29 days

Article editing time: 431 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2025 y Creative Commons. The Spanish Journal of Gastroenterology