Year 2020 / Volume 112 / Number 7
Letter
Systemic inflammatory response and thrombosis due to alterations in the gut microbiota in COVID-19

584-585

DOI: 10.17235/reed.2020.7297/2020

Klaus Mönkemüller, Lucia C. Fry, Steffen Rickes,

Abstract
We thank Dr. Cienfuegos and colleagues for their comments on our recent publication “COVID-19, Coronavirus, SARS-CoV-2 and the small bowel”. Cienfuegos et al. have treated several COVID-19 patients with thromboembolic complications, including bowel ischemia. The authors correctly highlight the importance of this complication in COVID-19 patients, which has also been documented in autopsy studies.
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References
1. Mönkemüller K, Fry L, Rickes S. COVID-19, coronavirus, SARS-CoV-2 and the small bowel. Rev Esp Enferm Dig. 2020;112(5):383‐388. doi:10.17235/reed.2020.7137/2020
2. Cienfuegos et al. Rev Esp Enf Dig 2020
3. Wichmann D, Sperhake J-P, Lütgehetmann M, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Ann. Intern. Med. 2020. Available at: http://www.ncbi.nlm.nih.gov/pubmed/32374815. Accessed May 11, 2020.
4. Zhang H, Li HB, Lyu JR, et al. Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection [published online ahead of print, 2020 Apr 18]. Int J Infect Dis. 2020;96:19‐24. doi:10.1016/j.ijid.2020.04.027
5. Lamers MM, Beumer J, van der Vaart J, et al. SARS-CoV-2 productively infects human gut enterocytes [published online ahead of print, 2020 May 1]. Science. 2020;eabc1669. doi:10.1126/science.abc1669.
6. Perlot T, Penninger JM. ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect. 2013 Nov;15(13):866-73. doi:10.1016/j.micinf.2013.08.003. Epub 2013 Aug 17. Review. PubMed PMID: 23962453.
7. Zuo T, Zhang F, Lui GCY, et al. Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization [published online ahead of print, 2020 May 19]. Gastroenterology. 2020;S0016-5085(20)34701-6.
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Publication history

Received: 27/05/2020

Accepted: 29/05/2020

Online First: 24/06/2020

Published: 08/07/2020

Article Online First time: 28 days

Article editing time: 42 days


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