Year 2021 / Volume 113 / Number 7
Letter
Hepatic injury and COVID-19: pathogenic mechanisms or epiphenomena?

554-555

DOI: 10.17235/reed.2021.7851/2021

Javier A. Cienfuegos, Víctor Valentí, Fernando Rotellar,

Abstract
Ampuero J et al. analyzed the relationship between liver injury and clinical progression of the disease in a meta-analysis of over 5,000 COVID-19 patients. The authors reported an association between increased aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin levels with mortality, admission to Intensive Care and the development of complications, respectively.
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References
1. Javier Ampuero, Yolanda Sánchez, Maria Rosario Garcia-Lozano. et al. Impact of liver injury on the severity of COVID-19:Systematic Review with Meta-analysis. Rev Esp Enferm Digest. 2021. doi: 10.17235/reed.2020.7397/2020. online ahead of print
2. Wang Y, Liu S, Liu H, et al. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol. 2020;73(4):807–16.
3. Lei P, Zhang L, Han P, et al. Liver injury in patients with COVID-19: clinical profiles, CT findings, the correlation of the severity with liver injury. Hepatol Int. 2020 1;14(5):733–42.
4. Sonzogni A, Previtali G, Seghezzi M, et al. Liver histopathology in severe COVID 19 respiratory failure is suggestive of vascular alterations. Liver Int. 2020 1;40(9):2110–6.
5. Nicolai L, Leunig A, Brambs S, et al. Immunothrombotic dysregulation in COVID-19 pneumonia is associated with respiratory failure and coagulopathy. Circulation. 2020;1176–89.
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Cienfuegos J, Valentí V, Rotellar F. Hepatic injury and COVID-19: pathogenic mechanisms or epiphenomena?. 7851/2021


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Publication history

Received: 01/02/2021

Accepted: 02/02/2021

Online First: 11/02/2021

Published: 07/07/2021

Article Online First time: 10 days

Article editing time: 156 days


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