Year 2016 / Volume 108 / Number 9
Case Report
Severe ischemic colitis following olanzapine use - A case report

595-598

DOI: 10.17235/reed.2016.3944/2015

Samuel R. Fernandes, Rosa Alves, Luís Araújo Correia, Ana Rita Gonçalves, João Malaquias, Emilia Oliveira, José Velosa,

Abstract
Ischemic colitis is the most common subtype of intestinal ischemia usually resulting from vasospasm, vessel occlusion or mesenteric hypoperfusion. Neuroleptics have seldom been linked to ischemic colitis by blocking peripheral anticholinergic and antiserotonergic receptors inducing severe gastrointestinal paresis. We report a young patient with severe ischemic colitis requiring surgery due to necrosis of the bowel. After exclusion of other potential causes, olanzapine was admitted as the cause of ischemia. Clinicians should be aware of how to recognize and treat the potentially life-threatening effects of neuroleptics.
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References
1 Higgins PD, Davis KJ, Laine L. Systematic review: The epidemiology of ischaemic colitis. Aliment Pharmacol Ther 2004;19: 729–38.
2 Park SJ, Gunn N, Harrison SA. Olanzapine and Benztropine as a Cause of Ischemic Colitis in a 27-year-old Man. J Clin Gastroenterol 2012;46: 515–7.
3 Green BT, Tendler DA. Ischemic Colitis: A Clinical Review. South Med J. 2005;98:217–22.
4 Parfitt JR, Driman DK. Pathological effects of drugs on the gastrointestinal tract: a review. Hum Pathol. 2007;38:527–36.
5 Palmer SE, McLean RM, Ellis PM, et al. Life-threatening clozapine-induced gastrointestinal hypomotility: An analysis of 102 cases. J Clin Psychiatry. 2008;69:759–68.
6 Hayes G, Gibler B. Clozapine-induced constipation. Am J Psychiatry. 1995;152:298.
7 Hibbard KR, Propst A, Frank DE, et al. Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports. Psychosomatics 2009; 50: 416–9.
8 Flanagan RJ, Ball RY. Gastrointestinal hypomotility: An under-recognised life-threatening adverse effect of clozapine. Forensic Sci Int. 2011;206:e31-6.
9 Bymaster FP, Calligaro DO, Falcone JF, et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996;14:87–96.
10 Peyrière H, Roux C, Ferard C, et al. Antipsychotics-induced ischaemic colitis and gastrointestinal necrosis: A review of the French pharmacovigilance database. Pharmacoepidemiol Drug Saf. 2009;18:948–55.
11 Ausseur A, Leroy C, Bazin B, et al. Acute necrotizing enterocolitis during a prolonged treatment with neuroleptics. Presse Med. 1995;24:577–9.
12 Larrey D1, Lainey E, Blanc P, et al. Acute colitis associated with prolonged administration of neuroleptics. J Clin Gastroenterol 1992;14:64–7.
13 De Hert M, Hudyana H, Dockx L, et al. Second-generation antipsychotics and constipation: A review of the literature. Eur Psychiatry. 2011;26:34–44.
14 Chengappa KN, Pollock BG, Parepally H, et al. Anticholinergic differences among patients receiving standard clinical doses of olanzapine or clozapine. J Clin Psychopharmacol 2000;20:311-6.
15 Leong QM, Wong KS, Koh DC. Necrotising colitis related to clozapine? A rare but life threatening side effect. World J Emerg Surg. 2007;2:21.
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Fernandes S, Alves R, Araújo Correia L, Rita Gonçalves A, Malaquias J, Oliveira E, et all. Severe ischemic colitis following olanzapine use - A case report. 3944/2015


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Publication history

Received: 25/07/2015

Accepted: 07/08/2015

Online First: 20/01/2016

Published: 06/09/2016

Article revision time: 10 days

Article Online First time: 179 days

Article editing time: 409 days


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