Year 2022 / Volume 114 / Number 6
Letter
Hypophosphatemic osteomalacia, a side effect of iron carboxymaltose administration

358

DOI: 10.17235/reed.2022.8621/2022

Lucía Madero Velázquez, Roser Muñoz Pérez, Andrés Rodríguez, Lorena Bernal, Beatriz Orts, Laura Sempere, Ana Gutiérrez Casbas,

Abstract
Carboxymaltose iron (Ferinject®) is a formulation for intravenous (iv) administration, used for the treatment of iron deficiency anemia and/or iron deficiency when oral administration of iron is not effective or due to intolerance. Its safety profile is excellent with few, but not nonexistent, side effects. Hypophosphatemia has been described as one of them. It is usually mild, transient and asymptomatic. However, in some cases it may be accompanied by nausea, asthenia, in addition to muscular and neurological symptoms and hematological alterations. It is, therefore, a potentially serious adverse effect whose prevalence is unknown and which requires high clinical suspicion to be detected.
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13/06/2022 11:21:33
Buena información , le tendremos presente


References
1.Musgrove J, Wolf M. Editorial: awareness and prevention of intravenous iron-induced hypophosphatemia. Aliment Pharmacol Ther. 2019;50:611-612.
2.Detlie TE, Lindstrøm JC, Jahnsen ME, et al. Incidence of hypophosphatemia in patients with inflammatory bowel disease treated with ferric carboxymaltose or iron isomaltoside. Aliment Pharmacol Ther. 2019;50:397-406.
3.Barish CF, Koch T, Butcher A, Morris D, Bregman DB. Safety and efficacy of intravenous ferric carboxymaltose (750 mg) in the treatment of iron deficiency anemia: two randomized controlled trials. Anemia. 2012;2012:172104.
4.Anand G, Schmid C. Severe hypophosphataemia after intravenous iron administration. BMJ Case Rep. 2017;2017:bcr2016219160.
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Madero Velázquez L, Muñoz Pérez R, Rodríguez A, Bernal L, Orts B, Sempere L, et all. Hypophosphatemic osteomalacia, a side effect of iron carboxymaltose administration. 8621/2022


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Publication history

Received: 19/01/2022

Accepted: 25/01/2022

Online First: 02/02/2022

Published: 07/06/2022

Article Online First time: 14 days

Article editing time: 139 days


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