Year 2011 / Volume 103 / Number 1
Puntos De Vista
Molecular basis of colorectal cancer: Towards an individualized management?

pp. 29-35

J. Perea, M. Lomas y M. Hidalgo

Abstract
Colorectal cancer (CRC) has become a highly relevant condition nowadays. In this respect, advances in the understanding of its molecular basis are key for an adequate management. From
the time when the adenoma-carcinoma sequence was formulated as a carcinogenesis model to this day, when, among other things, three major carcinogenic pathways have been identified, the CRC concept has evolved from that of a single disease to the notion that each CRC is a differentiated condition in itself. The suppressor
or chromosome instability pathway, the mutator or microsatellite instability pathway, and the methylator or CpG island methylation
pathway allow various phenotypes to be identified within CRC. Similarly, the presence of different changes in certain genes confers several behaviors on CRC from both the prognostic and
responsive standpoints to specific therapies. However, this apparent complexity does help develop the clinical management of this
disease through the identification of novel, more specific therapy targets, and also markers for various behaviors within the condition,
which will most likely lead us to an individualized management for these patients.
Share Button
New comment
Comments
No comments for this article
Related articles
Citation tools
J. Perea, M. Lomas y M. Hidalgo. Molecular basis of colorectal cancer: Towards an individualized management?. 29-35


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 660 visits.
This article has been downloaded 8 times.
Share
This article has been rated by 2 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology