Year 2025 / Volume 117 / Number 3
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Sclerosing angiomatoid nodular transformation (SANT), a rare splenic tumor with increasing incidence

148-150

DOI: 10.17235/reed.2023.9713/2023

Irene López Rojo, Ana Teijo Quintans, Raquel Saiz Martínez, Patricia Muñoz Hernández, Óscar Alonso-Casado,

Abstract
SANT (sclerosing angiomatoid nodular transformation) tumor is a rare splenic tumor of unknown etiology and vascular lineage, first described in 2004. Most cases are asymptomatic, although cases of anemia or abdominal pain in association with growth have been described. Spontaneous ruptures have not been described. Radiologically it presents a radial pattern with centripetal filling in dynamic MRI, being a characteristic feature, but not pathognomonic. It may present hypermetabolism in PET-CT. Its incidence is increasing since its description as an independent clinical and histopathological entity, especially in the oncological patients follow-up. Due to its radiological resemblance to metastatic lesions and its growth despite being a vascular lesion, splenectomy is indicated following the principles of oncologic surgery until a definitive diagnosis is made. It presents a benign behavior, requiring neither treatment nor specific subsequent surveillance. Two diagnosed cases of SANT are presented, as well as a review of the clinical, radiological and histopathological characteristics of this little-known splenic lesion.
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References
1. Martel M, Cheuk W, Lombardi L, Lifschitz-Mercer B, Chan JK, Rosai J. Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion. Am J Surg Pathol. 2004;28(10):1268-79
2. Koyama R, Minagawa N, Maeda Y, Shinohara T, Hamada T. A sclerosing angiomatoid nodular transformation (SANT) mimicking a metachronous splenic metastasis from endometrioid cancer and ovarian cancer. Int J Surg Case Rep. 2019; 65:292-295
3. Tseng H, Ho CM, Tien YW. Reappraisal of surgical decision-making in patients with splenic sclerosing angiomatoid nodular transformation: Case series and literature review. World J Gastrointest Surg. 2021;13(8):848-858
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López Rojo I, Teijo Quintans A, Saiz Martínez R, Muñoz Hernández P, Alonso-Casado Ó. Sclerosing angiomatoid nodular transformation (SANT), a rare splenic tumor with increasing incidence. 9713/2023


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Publication history

Received: 09/05/2023

Accepted: 18/05/2023

Online First: 14/06/2023

Published: 06/03/2025

Article Online First time: 36 days

Article editing time: 667 days


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