Year 2019 / Volume 111 / Number 2
Original
Intestinal IgA positive lymphocytes in acute liver necrosis decrease due to lymphocyte homing disturbance and apoptosis

101-105

DOI: 10.17235/reed.2018.5656/2018

Jinlong Fu, Guodong Li, Jianliang Wu, Zhiyong Wang,

Abstract
Aim: the number of intestinal IgA+ lymphocytes are decreased in acute liver necrosis and the mechanism remains poorly understood. The purpose of this study was to observe the role of lymphocyte homing and apoptosis associated with decreased intestinal IgA positive lymphocytes in acute liver necrosis. Methods: the acute liver necrosis mouse model and LTβR pre-treatment were used to assess intestinal mucosal addressin cell adhesion molecule-1 (MAdCAM - 1) expression, cell apoptosis, IgA+ cells and secretory immunoglobulin A (SIgA). Results: MAdCAM – 1 mRNA and protein expression decreased significantly in the acute necrosis group; 0.57 ± 0.032 fold vs. baseline (p < 0.05) and 0.45 ± 0.072 fold vs. baseline (p < 0.05), respectively. LTβR pre-treatment could significantly improve the decline of MAdCAM – 1 mRNA and protein expression in the intestinal mucosa (1.83 ± 0.064 fold vs. baseline, p < 0.05 and 1.75 ± 0.046 fold vs. baseline, p < 0.05, respectively) and partially restore the decline in IgA+ lymphocytes and SIgA levels. There were increased rates of enterocyte apoptosis in both the acute liver necrosis and LTβR pre-treatment group; 0.79% vs. control (p < 0.05) and 0.77% vs. control (p < 0.05), respectively). Conclusion: our results suggest that the dysfunction of lymphocyte homing and apoptosis are both involved with decreased intestinal IgA+ lymphocytes in acute liver necrosis. LTβR pre-treatment can partially restore IgA+ cells and SIgA by increasing MAdCAM – 1 expression, rather than inhibiting lymphocyte apoptosis.
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References
1.Iebba V, Nicoletti M, Schippa S. Gut microbiota and the immune system: an intimate partnership in health and disease. Int J Immunopathol Pharmacol 2012;25(4):823-33.
2.Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol 2012;12(12):821-32.
3.Nagler-Anderson C. Man the barrier! Strategic defences in the intestinal mucosa. Nat Rev Immunol 2001;1(1):59-67.
4.Mantis NJ, Rol N, Corthésy B. Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol 2011;4(6):603-11.
5.Fu JL, Wang ZH, Li GZ, et al. Decreased IgA+ plasma cells and IgA expression in acute liver necrosis mice. World J Gastroenterol 2010;16(30):3827-33.
6.Kobayashi M, Hoshino H, Suzawa K, et al. Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases. Semin Immunopathol 2012;34(3):401-13.
7.Hart AL, Ng SC, Mann E, et al. Homing of immune cells: role in homeostasis and intestinal inflammation. Inflamm Bowel Dis 2010;16(11):1969-77.
8.Jin-Long Fu, Yu-Rong Wang, Guo-Zhen Li, et al. Change in Expression of the Intestinal Polymeric Immunoglobulin Receptor in Acute Liver Necrosis. Journal Of GHR 2012;1(5): 69-73.
9.Liu DY, Li JJ. Effect of hyperoxia on the intestinal IgA secretory component in neonatal rats and on intestinal epithelial cells in vitro. Braz J Med Biol Res 2010;43(11):1034-41.
10.Guo-Zhen Li, Zhao-Han Wang, Wei Cui, et al. Tumor necrosis factor alpha increases intestinal permeability in mice with fulminant hepatic necrosis. World J Gastroenterol 2012;18(36): 5042-50.
11.Qiao SF, Lu TJ, Sun JB, et al. Alterations of intestinal immune function and regulatory effects of L-arginine in experimental severe acute pancreatitis rats. World J Gastroenterol 2005;11(39):6216-8.
12.Woodside KJ, Spies M, Wu XW, et al. Decreased lymphocyte apoptosis by anti-tumor necrosis factor antibody in Peyer's patches after severe burn. Shock 2003;20(1):70-3.
13.Swidsinski A, Loening-Baucke V, Theissig F, et al. Comparative study of the intestinal mucus barrier in normal and inflamed colon. Gut 2007;56(3):343-50.
14.Berlin C, Berg EL, Briskin MJ, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993;74:185-5.
15.Schippers A, Leuker C, Pabst O, et al. Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice. Gastroenterology 2009;137(3):924-33.
16.Aida Habtezion, Linh P. Nguyen, Husein Hadeiba, Eugene C. Butcher. Leukocyte Trafficking to the Small Intestine and Colon. Gastroenterology 2016; 150(2): 340-54.
17.R Hokari, S Kato, K Matsuzaki, et al. Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats. Clin Exp Immunol 2001; 126(2): 259-65.
18.Macho-Fernandez E, Koroleva EP, Spencer CM, et al. Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells. Mucosal Immunol 2015;8(2):403-13.
19.Dejardin E, Droin NM, Delhase M, et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 2002;17:525-35.
20.Kang W, Kudsk KA, Sano Y, et al. Effects of lymphotoxin beta receptor blockade on intestinal mucosal immunity. J Parenter Enteral Nutr 2007;31(5):358-64.
21.Kang HS, Chin RK, Wang Y, et al. Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production. Nat Immunol 2002;3(6):576-82.
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Fu J, Li G, Wu J, Wang Z. Intestinal IgA positive lymphocytes in acute liver necrosis decrease due to lymphocyte homing disturbance and apoptosis. 5656/2018


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Publication history

Received: 15/04/2018

Accepted: 26/08/2018

Online First: 15/10/2018

Published: 01/02/2019

Article revision time: 121 days

Article Online First time: 183 days

Article editing time: 292 days


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