Year 2023 / Volume 115 / Number 10
Digestive Diseases Image
Severe gastritis in a patient treated with immunotherapy: immune-mediated or reactivation of cytomegalovirus?

578-579

DOI: 10.17235/reed.2022.9158/2022

Sonia Rebeca Vallejo Rivera, Lidia Nicolás Niza, Lucía Bonilla López, Juan Díaz Concepción,

Abstract
Cancer patients receiving programmed death 1 (PD-1) immune checkpoint blockade therapy are susceptible, due to immunosuppression, to a variety of infections including cytomegalovirus infection. We report an unusual case of histologically confirmed gastritis due to cytomegalovirus infection in a patient who had metastatic melanoma and received PD-1 blockade therapy with pembrolizumab. Pembrolizumab was discontinued and treatment with intravenous ganciclovir and oral vangaciclovir was initiated; the patient's symptoms improved significantly.
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References
Lu J, Firpi-Morell RJ, Dang LH, et al. An Unusual Case of Gastritis in One Patient Receiving PD-1 Blocking Therapy: Coexisting Immune-Related Gastritis and Cytomegaloviral Infection. Gastroenterol Res. 2018;11:383–7.
Hulo P, Touchefeu Y, Cauchin E, et al. Acute Ulceronecrotic Gastritis With Cytomegalovirus Reactivation: Uncommon Toxicity of Immune Checkpoint Inhibitors in Microsatellite Instability–High Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2020;19:e183–8.
Ojeda Gómez A, Jiménez García N, Barragán Martínez J, et al. Acute neutrophilic gastritis induced by nivolumab used as treatment for non- metastatic malignant melanoma. Rev Esp Enferm Dig. 2021 Dec;113(12):853-854.
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Citation tools
Vallejo Rivera S, Nicolás Niza L, Bonilla López L, Díaz Concepción J. Severe gastritis in a patient treated with immunotherapy: immune-mediated or reactivation of cytomegalovirus? . 9158/2022


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Publication history

Received: 26/08/2022

Accepted: 14/09/2022

Online First: 07/10/2022

Published: 09/10/2023

Article Online First time: 42 days

Article editing time: 409 days


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