Year 2018 / Volume 110 / Number 6
Case Report
Hepatitis E virus in neurological disorders: a case of Parsonage-Turner syndrome

402-403

DOI: 10.17235/reed.2018.5506/2018

María Sánchez Azofra, Miriam Romero Portales, Lucia Tortajada Laureiro, Javier García-Samaniego, Pedro Mora Sanz,

Abstract
Hepatitis E virus (HEV) infection is an emerging disease in developed countries with a broad clinical spectrum. In the absence of immunodeficiency or pregnancy, it is a mild and almost asymptomatic condition in most cases. However, extrahepatic manifestations, including neurological conditions, are common and may occasionally lead to permanent neurological sequelae. Herein, we report the case of an immunocompetent patient who was admitted to our hospital with paresthesia and weakness in both the upper extremities associated with anicteric-elevated transaminases. The diagnosis was Parsonage-Turner syndrome (neuralgic amyotrophy) secondary to HEV infection. The diagnosis was reached via electromyography and serology tests. Neuralgic amyotrophy (NA) is a demyelinating axonal disease that affects the brachial plexus and is associated with HEV infection in up to 10% of cases. We also emphasize the importance of requesting HEV serology in patients with neurological disease, especially with the involvement of the peripheral nervous system. Although the role of ribavirin remains to be fully determined, early diagnosis and treatment may result in an improved prognosis, thereby minimizing neurological sequelae.
Share Button
New comment
Comments
No comments for this article
References
1. Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Eijk AA Van Der. Review Hepatitis E virus : Infection beyond the liver ? J Hepatol [Internet]. 2018;66(5):1082–95. Available from: http://dx.doi.org/10.1016/j.jhep.2016.11.016
2. Jeroen J.J. van Eijk M, Madden RG, BMBS, Eijk AA van der, MD, Jeremy G. Hunter B, et al. Neuralgic amyotrophy and hepatitis E virus infection. Am Acad Neurol. 2014
3. Debing Y, Moradpour D, Neyts J, Gouttenoire J. Review Update on hepatitis E virology : Implications for clinical practice. J Hepatol [Internet]. 2018;65(1):200–12. Available from: http://dx.doi.org/10.1016/j.jhep.2016.02.045
4. Scanvion Q, Perrez T, Cassim F, Outteryck O, Lanteri A, Hatron P, et al. Neuralgic amyotrophy triggered by hepatitis E virus : a particular phenotype To cite this version : HAL Id : hal-01503940 Neuralgic amyotrophy triggered by hepatitis E virus : a particular phenotype. J Neurol. 2017;264 (4):770–80.
5. Dalton HR, Ripellino P, Madden RG, Jones C, Fritz M, Gobbi C, et al. Clinical phenotype and outcome of hepatitis E virus – associated neuralgic amyotrophy. Am Acad Neurol. 2017;89:909–17. DOI: 10.1212/WNL.0000000000004297
6. Dalton HR, Eijk JJJ Van, Cintas P, Bendall RP, Mclean BN, Jacobs BC, et al. Hepatitis E virus infection and acute non-traumatic neurological injury : A prospective multicentre study Hepatitis E virus infection and acute non-traumatic. J Hepatol [Internet]. 2018;67(5):925–32. Available from: https://doi.org/10.1016/j.jhep.2017.07.010
7. Perrin HB, Cintas P, Abravanel F, Gérolami R, Alteroche L, Raynal J, et al. Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E. Emerg Infect Dis. 2015;21(11).
Citation tools
Sánchez Azofra M, Romero Portales M, Tortajada Laureiro L, García-Samaniego J, Mora Sanz P. Hepatitis E virus in neurological disorders: a case of Parsonage-Turner syndrome. 5506/2018


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1087 visits.
This article has been downloaded 285 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 29/01/2018

Accepted: 22/02/2018

Online First: 12/04/2018

Published: 31/05/2018

Article revision time: 19 days

Article Online First time: 73 days

Article editing time: 122 days


Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology