Year 2007 / Volume 99 / Number 12
Original
Immuno-expression of p53 and cyclin D1 in adenomas of the gallbladder

pp. 694-697

Arévalo, F. / Arias Stella, C. / Monge, E.

Abstract
Introduction: gallbladder adenomas are infrequent neoplasms whose relation to adenocarcinoma is not well understood. It has been suggested that adenomas and adenocarcinomas follow different molecular pathways.

Material and methods: this is a comparative, cross-sectional study in which we compared p53 and D1 cyclin expression in adenomas and adenocarcinomas of the gallbladder.

Results: we included 12 cases in each group. Expression of p53 occurred in 83.3% of adenocarcinomas and in 16.6% of adenomas (p = 0.003). D1 cyclin was expressed in a similar number of adenomas and adenocarcinomas.

Conclusion: our results support the hypothesis that p53 is an important step in the pathogenesis of adenocarcinomas but not of adenomas of the gallbladder. D1 cyclin is apparently a common pathway involved in the genesis of both tumors.
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Arévalo, F. / Arias Stella, C. / Monge, E.. Immuno-expression of p53 and cyclin D1 in adenomas of the gallbladder. 694-697


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