Year 2021 / Volume 113 / Number 6
Original
Overall clinical and economic impact of non-alcoholic fatty liver disease

396-403

DOI: 10.17235/reed.2020.7238/2020

Antoni Sicras-Mainar, Rocío Aller, Javier Crespo, José Luis Calleja, Juan Turnes, Manuel Romero Gómez, Salvador Augustín,

Abstract
Objectives: to establish the clinical and economic consequences (resource utilization and healthcare costs) of non-alcoholic fatty liver in the setting of the usual clinical practice in Spain. Patients and methods: an observational, retrospective study was performed based on a review of the medical records of adult patients ≥ 18 years of age who sought medical care from 2017 to 2018. Patients were categorized into two groups according to fibrosis stage (estimation method: FIB-4): a) F0-F2; and b) F3-F4 (advanced fibrosis). Follow-up lasted one year. Primary endpoints included comorbidity, concomitant medication, resource utilization and costs. Results were analyzed using a multivariate approach with p < 0.05. Results: a total of 8,151 patients were recruited with a mean age of 61.1 years and 51.5 % were male. By group: a) mild fibrosis n = 7,127, 87.4 %; and b) advanced fibrosis n = 1,024, 12.6 % (6.8 % with liver cirrhosis). The most common comorbidities included 63 % dyslipidemia, 52 % obesity, 52 % hypertension and 35 % diabetes. The average number of drugs used was 2.1 per patient. Patients with advanced fibrosis (F3-F4) had a higher average number of concomitant medications (2.5 vs 2.1; p < 0.001) and a higher AST/ALT ratio (1.1 vs 0.8; p < 0.001). The average cost (patient-year) for subjects with advanced fibrosis, corrected for covariates, was higher (€1,812 vs €1,128, p < 0.001). Age, morbidity, concomitant medication, fibrosis stage and total costs were higher in patients with diabetes. Conclusions: patients with advanced fibrosis were associated with more comorbidity and concomitant medications, which resulted in higher healthcare costs for the National Health System.
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doi:https://doi.org/10.1016/j.artere.2016.06.001
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Sicras-Mainar A, Aller R, Crespo J, Calleja J, Turnes J, Romero Gómez M, et all. Overall clinical and economic impact of non-alcoholic fatty liver disease. 7238/2020


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Publication history

Received: 08/05/2020

Accepted: 14/06/2020

Online First: 23/11/2020

Published: 04/06/2021

Article revision time: 32 days

Article Online First time: 199 days

Article editing time: 392 days


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