Year 2022 / Volume 114 / Number 6
Letter
Upper gastrointestinal bleeding secondary to toxicity by anthracyclines, cytarabine and methotrexate in a patient with acute lymphoblastic leukemia

363-364

DOI: 10.17235/reed.2022.8639/2022

Alejandro García Martínez, Juan Cristóbal Aguilar Martínez, Lidia Campos Gonzaga, Daniel Mateos Millán,

Abstract
A 60-year-old male patient with no medical history but acute lymphoblastic leukemia was admitted in the hematology ward for chemotherapy treatment (methotrexate, cytarabine, fludarabine and idarubicin). Approximately six days after finishing this chemotherapy, the patient began with symptoms of upper gastrointestinal bleeding (hematemesis and melena). Gastroscopy revealed erosive esophagitis, gastritis and duodenitis, as well as Forrest III ulcers in the duodenal bulb and multiple Forrest IIb ulcers in the second portion of the duodenum. Given the multiplicity of lesions, medical treatment with high doses of folinic acid, intravenous omeprazole, and transfusion of blood products was decided, with favorable evolution of the gastrointestinal bleeding. However, the patient died of respiratory infection.
Share Button
New comment
Comments
No comments for this article
References
1. Boussios S, Pentheroudakis G, Katsanos K, et al. Systemic treatment-induced gastrointestinal toxicity: incidence, clinical presentation and management. Annals of Gastroenterology. 2012; 25:106-118.
2. Peker Y, Yarkier H and Akar H. Gastrointestinal bleeding secondary to use of high-dose methotrexate: A case report. J Surg Med. 2018; 2(2): 151-153.
3. Tsukada T, Nakano T, Miyata T, et al. Life-Threatening Gastrointestinal Mucosal Necrosis during Methotrexate Treatment for Rheumatoid Arthritis. Case Rep Gastroenterol. 2013; 7: 470-475.
4. Liu Y, Hiramoto B, Kwok J et al. Taxane-induced upper Gastrointestinal Bleeding. Case Repo Oncol. 2021;14:1373-1379.
5. Sánchez Cánovas M and López Martín A. Severe gastrointestinal toxicity secondary to fluoropyrimidines: acute esophageal necrosis associated extensive duodenal mucositis. Rev Esp Enferm Dig. 2020. doi: 10.17235/reed.2020.7500/2020. Online ahead of print.
Related articles

Letter

Upper gastrointestinal bleeding and Rigler triad

DOI: 10.17235/reed.2023.9731/2023

Letter

A full hemostatic repertoire in a complex cirrhotic patient

DOI: 10.17235/reed.2022.9039/2022

Letter

Sepsis due to phlegmonous gastritis in a cancer patient

DOI: 10.17235/reed.2022.9009/2022

Digestive Diseases Image

Bezoar: an uncommon cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2021.8311/2021

Letter

COVID-19 and aorto-enteric fistula

DOI: 10.17235/reed.2021.8272/2021

Digestive Diseases Image

Gastroduodenal Burkitt’s lymphoma: a rare cause of epigastric pain and diarrhea

DOI: 10.17235/reed.2021.8150/2021

Letter to the Editor

Gangliocytic paraganglioma: an unusual cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2017.4808/2016

Case Report

Downhill varices: an uncommon cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2015.3697/2015

Citation tools
García Martínez A, Aguilar Martínez J, Campos Gonzaga L, Mateos Millán D. Upper gastrointestinal bleeding secondary to toxicity by anthracyclines, cytarabine and methotrexate in a patient with acute lymphoblastic leukemia. 8639/2022


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1380 visits.
This article has been downloaded 161 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 23/01/2022

Accepted: 24/01/2022

Online First: 01/02/2022

Published: 07/06/2022

Article Online First time: 9 days

Article editing time: 135 days


Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology