Year 2024 / Volume 116 / Number 3
Letter
Macro-AST as a cause of hypertransaminasemia: an uncommon entity but it exists

166-167

DOI: 10.17235/reed.2023.9628/2023

Miriam Celada-Sendino, Alejandra Fernández-Fernández, Manuel Rodríguez,

Abstract
Macroenzymes are complexes formed by the binding of enzyme molecules to each other or to other plasma components. We report the clinical case of a woman with abnormal liver enzymes secondary to macro-AST. Macro-AST should be considered in the differential diagnosis as a cause of isolated AST elevation, thus avoiding unnecessary additional tests.
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References
Lee M, Vajro P, Keeffe EB. Isolated aspartate aminotransferase elevation: think macro-AST. Dig Dis Sci. 2011;56:311-3.
Sánchez-Muñoz D, Romero-Gómez M, Moro A. Macro-AST as cause of unknown hypertransaminasaemia. Eur J Gastroenterol Hepatol. 2003;15:103-4.
González Raya A, Coca Zúñiga R, Martín Salido E. Isolated elevation of aspartate aminotransferase (AST) in an asymptomatic patient due to macro-AST. J Clin Lab Anal. 2019;33:e22690.
Rohani P, Imanzadeh F, Sayyari A, et al. Persistent elevation of aspartate aminotransferase in a child after incomplete Kawasaki disease: a case report and literature review. BMC Pediatr. 2020;20:73.
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Celada-Sendino M, Fernández-Fernández A, Rodríguez M. Macro-AST as a cause of hypertransaminasemia: an uncommon entity but it exists. 9628/2023


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Publication history

Received: 28/03/2023

Accepted: 30/03/2023

Online First: 19/04/2023

Published: 04/03/2024

Article Online First time: 22 days

Article editing time: 342 days


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