Year 2020 / Volume 112 / Number 12
Letter
Candesartan-induced cholestatic hepatitis: a case report

959-960

DOI: 10.17235/reed.2020.6988/2020

Benito Hermida Pérez, Marta Izquierdo Romero, Rosa García López,

Abstract
We present the case of a 55-year-old male that was admitted to our hospital for cholestatic hepatitis. Other causes of hepatitis were excluded with imaging, laboratory and serologic tests. A liver biopsy was performed, which was compatible with toxicity-induced hepatitis. Re-assessing the patient, he mentioned the start of treatment with candesartan cilexetil 3 weeks prior to the onset of the symptoms. Candesartan was withdrawn, with a progressive improvement in cholestasis and complete normalization of liver biochemistry at 6 months. The patient was diagnosed with candesartan-induced cholestatic hepatitis, probable according to CIOMS/RUCAM scale.
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References
1. Jiménez-Sáenz, M., Arroyo, Q., Sanjuan, M. et al. Hepatitis colestática por candesartan. Reporte de un caso. Gastroenterol. Hepatol. 2010 33, 66–67
2. Lammel-Lindemann, J. A., Flores-Villalba, E., Martagón, A. J., et al. Noncholestatic acute hepatocellular injury following candesartan administration. Br. J. Clin. Pharmacol. 2018 84, 204–207
3. Sturm, N., Hilleret, M.N., Dreyfus, T., et al. [Candesartan Cilexetil (Atacand) induced prolonged severe cholestasis improved by extracorporeal albumin dialysis]. Gastroenterol. Clin. Biol. 2005 29, 1299–1301
4. Vallejo, I., García Morillo, S., Pamies, E. [Acute hepatitis induced by Candesartan]. Med Clin. 2000, 719
5. Basile, G., Villari, D., Gangemi, S., et al. Candesartan Cilexetil-Induced Severe Hepatotoxicity. J. Clin. Gastroenterol. 2003 36, 273–275
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Hermida Pérez B, Izquierdo Romero M, García López R. Candesartan-induced cholestatic hepatitis: a case report. 6988/2020


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Publication history

Received: 18/02/2020

Accepted: 18/03/2020

Online First: 23/11/2020

Published: 09/12/2020

Article revision time: 18 days

Article Online First time: 279 days

Article editing time: 295 days


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