Year 2023 / Volume 115 / Number 4
Letter
Infection with SARS-CoV-2 as a potential achalasia trigger

203-204

DOI: 10.17235/reed.2022.8975/2022

Pilar Ruz Zafra, Carlos Javier García Sánchez, Alberto Pérez Ramírez, Ana Guil Soto, Eduardo Leo Carnerero,

Abstract
Idiopathic achalasia is a chronic oesophageal motility disorder caused by loss of inhibitory neurons at the esophageal myenteric plexus resulting in incomplete relaxation of the lower oesophageal sphincter and abnormal peristaltism.  Among the possible causes of this, an immune response secondary to infection by some viruses has been implicated. SARS-CoV-2 could be considered among them. The therapy option should be aimed at achieving the greatest clinical effectiveness according to each patient’s health status.
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References
1.Oude Nijhuis RAB, Zaninotto G, Roman S, Boeckxstaens GE, Fockens P, Langendam MW, Plumb AA, Smout A, Targarona EM, Trukhmanov AS, Weusten B, Bredenoord AJ. European guidelines on achalasia: United European Gastroenterology and European Society of Neurogastroenterology and Motility recommendations. United European Gastroenterol J. 2020 Feb;8(1):13-33. doi: 10.1177/2050640620903213. PMID: 32213062; PMCID: PMC7005998.
2.Furuzawa-Carballeda J, Aguilar-León D, Gamboa-Domínguez A, et al. Achalasia An Autoimmune Inflammatory Disease: A Cross-Sectional Study. J Immunol Res. 2015;2015:729217.
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Ruz Zafra P, García Sánchez C, Pérez Ramírez A, Guil Soto A, Leo Carnerero E. Infection with SARS-CoV-2 as a potential achalasia trigger . 8975/2022


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Publication history

Received: 30/05/2022

Accepted: 25/07/2022

Online First: 12/09/2022

Published: 03/04/2023

Article Online First time: 105 days

Article editing time: 308 days


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