Year 2016 / Volume 108 / Number 9
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Upper gastrointestinal bleeding in a patient with Sjögren syndrome

576

Margarida Cortes, Samuel Fernandes, Vitor Teixeira, Luis Carlos Freitas,

Abstract
A 68-year-old female patient with Sjögren syndrome was admitted with asthenia, anorexia and weight loss. On the third day of admission, she developed severe hematemesis. Urgent upper gastrointestinal endoscopy (UGE) showed multiple gastric and duodenal ulcers, some with active bleeding requiring endoscopic therapy. The anatomopathologic examination was compatible with gastric and duodenal infiltration by a diffuse CD20+ large B cell lymphoma with germinal center B cell–like morphology. And the patient was referred for chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone. Although seldom observed, the risk of lymphoma in Sjögren syndrome is up to 44 times higher than the general population and rises 7 years after diagnosis. We present a brief case report with interesting iconography.
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References
1. Voulgarelis M, Ziakas PD, Papageorgiou A, et al. Prognosis and Outcome of Non-Hodgkin Lymphoma in Primary Sjögren Syndrome. Medicine (Baltimore). 2012;91:1–9.
2. Nocturne G, Mariette X. Sjögren Syndrome-associated lymphomas: an update on pathogenesis and management. Br J Haematol 2015;168:317–27.
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Cortes M, Fernandes S, Teixeira V, Freitas L. Upper gastrointestinal bleeding in a patient with Sjögren syndrome. 3959/2015


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Publication history

Received: 06/08/2015

Accepted: 18/08/2015

Published: 06/09/2016

Article revision time: 8 days

Article editing time: 397 days


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