Year 2023 / Volume 115 / Number 7
Letter
Primary esophageal diffuse large B-cell lymphoma

400-401

DOI: 10.17235/reed.2022.9298/2022

Paloma Álvarez Martínez, Pedro José Ramos Martínez, Patricia García González, Alejandro Nieto-Jara, Celia del Caño Cerdán, Emilia García Riesco,

Abstract
A 76-year-old man presented with dysphagia, epigastric pain and weight loss for the last two months. Heavy sweating was also presented. Past medical conditions included type 2 diabetes. He had no evidence of any immunosupressive disease including HIV infection. Physical examination only revealed low-grade fever. Laboratory data showed leukocytosis. Gastroscopy evidenced a complete esophageal stenosis starting at 30 cm, with a severely friable mucosa of malignant appearance. The results of biopsies were insufficient for diagnosis of malignancy. Computed tomography demonstrated a 10-cm irregular tumor located in the distal and middle thirds of the esophagus, which resulted in narrowing of the lumen. Involving tracheal carina, bronchus, and descending aorta were observed. Perforation signs were also seen. Distant metastases were not found. Empirical treatment with piperacillin/tazobactan was started. A surgical gastrostomy to allows nutritional support was performed. Two other gastroscopies were performed resulting in an inconclusive diagnosis. Finally, flow cytometry performed in samples obtained by endobronchial ultrasound-guided biopsy evidenced prominent clonal B-cell populations consistent with extranodal diffuse large B-cell lymphoma exhibing CD10 expression. A treatment with Rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was started. Primary esophageal diffuse large B-cell lymphoma (DLBCL), a variant of non-Hodgkin’s lymphoma, accounts for less than 1% of all cases of gastrointestinal lymphomas.
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Álvarez Martínez P, Ramos Martínez P, García González P, Nieto-Jara A, del Caño Cerdán C, García Riesco E, et all. Primary esophageal diffuse large B-cell lymphoma . 9298/2022


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Publication history

Received: 20/10/2022

Accepted: 26/10/2022

Online First: 10/11/2022

Published: 06/07/2023

Article Online First time: 21 days

Article editing time: 259 days


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