Year 2021 / Volume 113 / Number 9
Letter
Use of scopolamine butylbromide to facilitate specimen fixation after endoscopic submucosal dissection

688-689

DOI: 10.17235/reed.2021.7821/2021

Raúl Honrubia López, Yutaka Mitsunaga, Shu Hoteya,

Abstract
Endoscopic submucosal dissection (ESD) is a technique for the en bloc resection of early neoplastic lesions in the gastrointestinal tract. A step that must be carried out after excision is the pinning down of the specimen on a support plate such as a cork board to avoid artifacts because of tissue contraction. After ESD lesion borders usually curl up from contraction, hence this procedure must be carefully performed to prevent damaging the specimen. Recently, Nishizawa T, et al. reported that dropping adrenaline onto the lesion results in edge relaxation, which facilitates fixation. However, the use of other drugs—such as Buscapine—that induce gastrointestinal smooth muscle relaxation, potentially with similar effects, has not been described. Below, two ESD specimens from two different institutions are shown. These specimens correspond to gastric lesions. Buscapine is applied on their surface and the edges become relaxed, thus facilitating stretching and thus fixation. In conclusion, the use of Buscapine may help in the processing of excised lesions by facilitating pinning out and reducing damage risk for specimens.
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References
1. Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, et al. Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2015;47(9):829-54. DOI: 10.1055/s-0034-1392882
2. Nishizawa T, Kinoshita S, Mori H, et al. Use of adrenaline for specimen fixation after endoscopic submucosal dissection. Endoscopy 2019;51(8):E204. DOI: 10.1055/a-0866-9302
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Honrubia López R, Mitsunaga Y, Hoteya S. Use of scopolamine butylbromide to facilitate specimen fixation after endoscopic submucosal dissection . 7821/2021


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Publication history

Received: 23/01/2021

Accepted: 26/01/2021

Online First: 11/02/2021

Published: 07/09/2021

Article Online First time: 19 days

Article editing time: 227 days


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