Year 2024 / Volume 116 / Number 11
Letter
Turmeric associated liver injury (DILI) with susceptible HLA

650-651

DOI: 10.17235/reed.2024.10763/2024

Íñigo Jon Garaizabal Azkue, Agustín Castiella, Leire Aburruza Ucar, Silvia Torrente Iranzo, Eva Zapata Morcillo,

Abstract
We present a 35-year-old Caucasian woman that was sent to the Hepatology clinics of our hospital in December 2023 for new onset jaundice. Without significant past medical history, the patient presented with bloating and dyspepsia for a week. No neurological abnormalities were found. She reported occasional alcohol intake, denying other drug consumption. No recent vaccination. She reported taking an over-the-counter supplement containing turmeric (tablet with 60 mg of curcumin and 10mg of black pepper) twice daily for 2 months with the aim of speedy recovery after CrossFit. Blood analysis was remarkable for alanine transaminase (ALT) 2230 U/L, aspartate transaminase (AST) 916U/L, total bilirubin 10.5 mg/dl, and direct bilirubin 8.0mg/dl. Coagulation within range. Computed tomography revealed hepatic hemangiomas and cysts without biliary tract dilatation. Further laboratory workup including acute hepatitis serologies (VHA, VHB, VHC, VHE, HSV, VVZ, EBV, CMV and Parvovirus) and autoimmune profile were unremarkable, except for being carrier of HLA DRB1*04 and HLA B35:01*in genetical studies. Due to probable DILI diagnose, 8 points in CIOM/RUCAM scale, she was advised to stop Turmeric. She was followed up in our Hepatology clinics and observed how liver enzymes progressively down-trended. Our patient remained asymptomatic with normal liver enzymes three months after stopping the supplement intake.
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References
Halegoua-DeMarzio D, Navarro V, Ahmad J, et al. Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]. Am J Med. 2023 Feb;136(2):200-206. doi: 10.1016/j.amjmed.2022.09.026. Epub 2022 Oct 14. PMID: 36252717; PMCID: PMC9892270.
Teschke R, Eickhoff A, Schulze J, et al. Herb-induced liver injury (HILI) with 12,068 worldwide cases published with causality assessments by Roussel Uclaf Causality Assessment Method (RUCAM): an overview. Transl Gastroenterol Hepatol. 2021 Jul 25;6:51. doi: 10.21037/tgh-20-149. PMID: 34423172; PMCID: PMC8343418.
Lukefahr AL, McEvoy S, Alfafara C, et al. Drug-induced autoimmune hepatitis associated with turmeric dietary supplement use Case Reports 2018;2018:bcr-2018-224611.
Arzallus T, Izagirre A, Castiella A, et al. Drug induced autoimmune hepatitis after turmeric intake, Gastroenterología y Hepatología,Volume 46, Issue 10,2023, Pages 805-806,
Fernández Bermejo M, Masa Caballero A, Lozano Lozano Á. Curcumin and curcumoids: hepatoprotection or hepatotoxicity? Rev Esp Enferm Dig. 2022 May;114(5):304-305
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Garaizabal Azkue Í, Castiella A, Aburruza Ucar L, Torrente Iranzo S, Zapata Morcillo E. Turmeric associated liver injury (DILI) with susceptible HLA . 10763/2024


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Publication history

Received: 04/09/2024

Accepted: 06/09/2024

Online First: 19/09/2024

Published: 11/11/2024

Article Online First time: 15 days

Article editing time: 68 days


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