Year 2022 / Volume 114 / Number 4
Letter
Severe hepatotoxicity secondary to nintedanib

244-245

DOI: 10.17235/reed.2020.7585/2020

Marta Librero Jiménez, Clara Heredia Carrasco, María del Carmen Fernández Cano,

Abstract
Nintedanib is a multikinase inhibitor used for the treatment of pulmonary idiopathic fibrosis. We present the first report published to date of severe hepatotoxicity and jaundice secondary to nintedanib.
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References
1. Crestani B, Huggins JT, Kaye M, et al. Long-term safety and tolerability of nintedanib in patients with idiopathic pulmonary fibrosis: results from the open-label extension study, INPULSIS-ON. Lancet Respir Med 2019;7(1):60-8.
2. Richeldi L, Du Bois RM, Raghu G, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med 2014;370:2071-82.
3. Cottin V. The safety and tolerability of nintedanib in the treatment of idiopathic pulmonary fibrosis. Expert Opin Drug Saf 2017;16(7):857-65.
4. Informe de Posicionamiento Terapéutico de Nintedanib (Ofev®) para el tratamiento de la fibrosis pulmonar idiopática. AEMOS; 2016. Disponible en: https://www.aemps.gob.es/medicamentos-de-uso-humano/informes-de-posicionamiento-terapeutico/.
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Librero Jiménez M, Heredia Carrasco C, Fernández Cano M. Severe hepatotoxicity secondary to nintedanib. 7585/2020


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Publication history

Received: 12/10/2020

Accepted: 08/11/2020

Online First: 29/12/2020

Published: 07/04/2022

Article revision time: 22 days

Article Online First time: 78 days

Article editing time: 542 days


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