Year 2017 / Volume 109 / Number 11
Special Article
Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome. The SEPD perspective

788-794

DOI: 10.17235/reed.2017.5078/2017

Isabel Vera, F. Javier Júdez,

Abstract
Functional gut disorders, including diarrhea-predominant irritable bowel syndrome, are highly prevalent conditions worldwide that significantly impact health economy and patient quality of life, yet lacking fully satisfactory therapeutic options. These circumstances fostered research on various molecules with more specific therapeutic targets, including opioid receptors. Eluxadoline (Allergan’s Vibercy® in the USA, Truberzi® in Europe) is a locally-acting mixed mu- and kappa-opioid receptor agonist, and delta-opioid receptor antagonist, that was licensed in 2015 by the Food and Drug Administration (FDA) and in 2016 by the European Medicines Agency (EMA) for use in diarrhea-predominant irritable bowel syndrome. Eluxadoline provides, with advantage over the current standard of care, control of both stool consistency and abdominal pain, good tolerability in most cases, and improved quality of life, hence it deserves consideration when approaching a patient with this disorder. As with any recently approved therapy, adequate pharmacovigilance is to be expected, as well as studies to inform on different scenarios such as on-demand therapy, loss of response assessment, use as rescue therapy for other molecules, and cost-effectiveness, to further characterize and more accurately position eluxadoline within the therapeutic spectrum.
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Vera I, Júdez F. Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome. The SEPD perspective. 5078/2017


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Publication history

Received: 23/05/2017

Accepted: 14/07/2017

Online First: 27/07/2017

Published: 02/11/2017

Article revision time: 48 days

Article Online First time: 65 days

Article editing time: 163 days


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