Year 2023 / Volume 115 / Number 4
Letter
Tolvaptan in portal hypertension: real life experience

206

DOI: 10.17235/reed.2022.9145/2022

Marta Tejedor, Agustín Delgado, Rosa Melero, Víctor Fernández-Alonso, Magdalena Salcedo, Patrocinio Rodríguez-Benítez,

Abstract
Tolvaptan (TVP) is a selective antagonist of vasopressin receptors, approved for the treatment of hyponatremia in SIADH, congestive heart failure (CHF) and cirrhosis. We retrospectively reviewed all cases where TVP was used in a tertiary hospital (January 2012- January 2017). Our aim was to study the use of TVP in real life practice in patients with portal hypertension (PHT) (past history of non-malignant ascites or variceal bleed).
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References
1. Schrier RW, Gross P, Gheorghiade M, Berl T, Verbalis JG, Czerwiec FS, Orlandi C; SALT Investigators. Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med. 2006 Nov 16;355(20):2099-112. doi: 10.1056/NEJMoa065181. Epub 2006 Nov 14. PMID: 17105757.
2. Berl T, Quittnat-Pelletier F, Verbalis JG, Schrier RW, Bichet DG, Ouyang J, Czerwiec FS; SALTWATER Investigators. Oral tolvaptan is safe and effective in chronic hyponatremia. J Am Soc Nephrol. 2010 Apr;21(4):705-12. doi: 10.1681/ASN.2009080857. Epub 2010 Feb 25. Erratum in: J Am Soc Nephrol. 2010 Aug;21(8):1407. PMID: 20185637; PMCID: PMC2844305.
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Citation tools
Tejedor M, Delgado A, Melero R, Fernández-Alonso V, Salcedo M, Rodríguez-Benítez P, et all. Tolvaptan in portal hypertension: real life experience. 9145/2022


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Publication history

Received: 21/08/2022

Accepted: 29/08/2022

Online First: 12/09/2022

Published: 03/04/2023

Article Online First time: 22 days

Article editing time: 225 days


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