Year 2024 / Volume 116 / Number 9
Original
Effectiveness and safety of a GLP-1 agonist in obese patients with inflammatory bowel disease

478-483

DOI: 10.17235/reed.2024.10305/2024

Clara Ramos Belinchón, Helena Martínez-Lozano, Clara Serrano Moreno, Diego Hernández Castillo, Pablo Lois Chicharro, Pablo Ferreira Ocampo, Ignacio Marín-Jiménez, Irene Bretón Lesmes, Luis Menchén,

Abstract
Background: obesity affects many patients with inflammatory bowel disease (IBD). Glucagon-like peptide (GLP)-1 agonists are a promising therapy for obese patients. However, there is a lack of evidence of the use of these drugs in IBD patients. This study investigated the effectiveness and safety of GLP-1 agonists in a cohort of obese patients with IBD. Methods: a retrospective series of cases of consecutive IBD patients who received GLP-1 agonists indicated to treat obesity between 2019 and 2021 was analyzed. The GLP-1 agonists included were semaglutide 1.0 mg or liraglutide 3.0 mg. The coprimary endpoints were the percentage of change in body weight from baseline to six months and a weight reduction of 5 % or more at six months. In addition, the safety profile of GLP-1 agonist therapy and its impact on the IBD course were reviewed. Results: sixteen obese patients with IBD (nine with Crohn’s disease [CD] and seven with ulcerative colitis [UC]) were included in the study. The median body mass index at baseline was 35 (32-37). The percentage of change in body weight was -6.2 % (-3.4-[-8.5]) at six months, and a 5 % or more weight reduction was achieved in 58.3 % (7/12) of patients at six months. The most common side effect was nausea (13.3 %), and one patient withdrew due to diarrhea. IBD activity score did not change significantly during follow-up. Conclusion: our results showed that GLP-1 agonists were effective and had a good safety profile in IBD patients. Most adverse effects were mild, and the IBD activity had no significant changes.
Lay Summary
Obesity prevalence is increasing among patients with inflammatory bowel disease; Glucagon-like peptide (GLP)-1 agonists are commonly used for diabetes mellitus, and their indication for obesity has increased in the last few years. In this observational study, GLP-1 agonists were effective, in terms of body weight reduction, and safe in obese IBD patients.
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Ramos Belinchón C, Martínez-Lozano H, Serrano Moreno C, Hernández Castillo D, Lois Chicharro P, Ferreira Ocampo P, et all. Effectiveness and safety of a GLP-1 agonist in obese patients with inflammatory bowel disease. 10305/2024


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Publication history

Received: 27/01/2024

Accepted: 07/05/2024

Online First: 20/05/2024

Published: 09/09/2024

Article revision time: 81 days

Article Online First time: 114 days

Article editing time: 226 days


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