Year 2022 / Volume 114 / Number 7
Original
Radon exposure and inflammatory bowel disease in a radon prone area

405-409

DOI: 10.17235/reed.2021.8239/2021

Violeta Mauriz-Barreiro, Manuel Barreiro-de Acosta, Iria Bastón-Rey, Rocío Ferreiro-Iglesias, Cristina Calviño-Suárez, Juan Miguel Barros-Dios, J. Enrique Domínguez-Munoz, Alberto Ruano-Raviña,

Abstract
Introduction: inflammatory bowel disease (IBD) is a multifactorial pathology with an increasing incidence. There is no study that has assessed a possible relationship with very high residential radon exposure in the study area. The aim of the study was to analyze if residential radon concentration is associated with a higher incidence of IBD. Material and methods: an ecological study was performed. All incident cases of inflammatory bowel disease in the area of Santiago de Compostela were included between January and December 2017. Radon levels at a municipal level were correlated with demographic factors and type of IBD. Results: ninety-six patients were included, 63 (65.6 %) with ulcerative colitis, 29 (30.25) with Crohn’s disease and four (4.2 %) with indeterminate colitis. The incidence rate per 100,000 inhabitants-year was 21.6 cases. There were no statistically significant differences in the type of disease developed regarding radon levels (p > 0.05). No correlation between radon levels and the cumulative incidence of inflammatory bowel disease at the municipal level was observed (Spearman’s rho = 0.13, p-value 0.5). Conclusion: in the area of Santiago de Compostela, there is a higher incidence of IBD in comparison with previous studies using western countries as reference. However, there was no correlation with the municipal average radon concentration and incidence of IBD or any of its types in this study.
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References
1. Barreiro-de-Acosta M, Mendoza JL, Lana R, et al. NOD2/CARD15: geographic differences in the Spanish population and clinical applications in Crohn's disease. Rev Esp Enferm Dig. 2010;102:321-6.
2. Malik TA. Inflammatory Bowel Disease: Historical Perspective, Epidemiology, and Risk Factors. Surg Clin North Am. 2015;95:1105-22.
3. Molodecky NA, Kaplan GG. Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2010;6:339-46.
4. Friedman S, Nørgård BM. Confirming Complexity: Assessing Environmental and Genetic Risk Factors for Inflammatory Bowel Disease. Gastroenterology. 2019 Jun;156(8):2124-2125.
5. Ng SC, Bernstein CN, Vatn MH, et al; Epidemiology and Natural History Task Force of the International Organization of Inflammatory Bowel Disease (IOIBD). Geographical variability and environmental risk factors in inflammatory bowel disease. Gut. 2013;62:630-49.
6. Amarapurkar AD, Amarapurkar DN, Rathi P, et al. Risk factors for inflammatory bowel disease: A prospective multi-center study. Indian J Gastroenterol. 2018;37:189-195.
7. Shivananda S, Lennard-Jones J, Logan R et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut. 1996;39:690-7.
8. Barreiro-de Acosta M, Magro F, Carpio D, et al. Ulcerative colitis in northern Portugal and Galicia in Spain. Inflamm Bowel Dis. 2010;16:1227-38.
9. Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142:46-54.e42
10. Barreiro-de Acosta M, Alvarez Castro A, Souto R, et al. Emigration to western industrialized countries: A risk factor for developing inflammatory bowel disease. J Crohns Colitis. 2011;5:566-9.
11. Carpio D, Barreiro-de Acosta M, Echarri A, et al. Influence of urban/rural and coastal/inland environment on the prevalence, phenotype, and clinical course of inflammatory bowel disease patients from northwest of Spain: a cross-sectional study. Eur J Gastroenterol Hepatol. 2015;27:1030-7.
12. Chaparro M, Garre A, Núñez Ortiz A, Diz-Lois Palomares MT, Rodríguez C, Riestra S, et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J Clin Med. 2021;10:2885.
13. Barros-Dios JM, Ruano-Ravina A, Gastelu-Iturri J, et al. Factors underlying residential radon concentration: results from Galicia, Spain. Environ Res. 2007;103:185-90.
14. Ruano-Ravina A, Cameselle-Lago C, Torres-Durán M, et al. Indoor Radon Exposure and COPD, Synergic Association? A Multicentric, Hospital-Based Case-Control Study in a Radon-Prone Area. Arch Bronconeumol (Engl Ed). 2020:S0300-2896(20)30539-1.
15. Maaser C, Sturm A, Vavricka SR, et al. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis. 2019;13:144-164.
16. Lorenzo-Gonzalez M, Ruano-Ravina A, Torres-Duran M, et al. Lung cancer risk and residential radon exposure: A pooling of case-control studies in northwestern Spain. Environ Res. 2020;189:109968.
17. Darby S, Hill D, Auvinen A, Barros-Dios JM, et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ. 2005;330(7485):223.
18. Ruano-Ravina A, Rodríguez MC, Cerdeira-Caramés S, et al. Residential radon and lung cancer. Epidemiology. 2009;20:155-6.
19. Radon. IARC Monogr Eval Carcinog Risks Hum. 1988;43:173-259.
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Mauriz-Barreiro V, Barreiro-de Acosta M, Bastón-Rey I, Ferreiro-Iglesias R, Calviño-Suárez C, Barros-Dios J, et all. Radon exposure and inflammatory bowel disease in a radon prone area. 8239/2021


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Publication history

Received: 26/07/2021

Accepted: 15/11/2021

Online First: 16/11/2021

Published: 07/07/2022

Article revision time: 104 days

Article Online First time: 113 days

Article editing time: 346 days


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