Year 2017 / Volume 109 / Number 8
Letter to the Editor
Use of abdominal ultrasound in the diagnosis of hepatic sinusoidal obstruction syndrome (SOS) in a patient receiving a hematopoietic-cell transplant

608-609

DOI: 10.17235/reed.2017.4823/2017

Marta Abadía Barnó, Eva Marín Serrano, Gloria Ruiz Fernández,

Abstract
The sinusoidal obstruction syndrome (SOS) is an uncommon form of portal hypertension that occurs in hematopoietic-cell transplant recipients who receive intense conditioning treatments. The diagnosis is clinical and it is usually delayed, because in these patients there are many causes that can damage the liver and can delay its detection. We present the case of a 47-year-old man, whose diagnosis was made with clinical and analytical data supported by ultrasound signs that showed hepatic congestion. After treatment with defibrotide the patient improved clinically and analytically. Hepatic vascularization and perfusion also improved. Therefore, abdominal doppler ultrasound is shown as a noninvasive exploration useful for the clinical management of SOS and as an early marker of good clinical evolution.
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References
1. Dignan FL, Wynn RF, Hadzic N, et al. BCSH/BSBMT guideline: Diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation. Br J Haematol. 2013;163(4):444–57.
2. McDonald G.B, Sharma P, Matthews D.E, et al. Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology. 1984;4(1):116-22
3. Rubbia-Brandt L. Sinusoidal Obstruction Syndrome. Clin Liver Dis. 2010;14(4):651–68
4. Fontanilla T, Hernando CG, Claros JC, et al. Acoustic radiation force impulse elastography and contrast-enhanced sonography of sinusoidal obstructive syndrome (Veno-occlusive Disease): preliminary results. J Ultrasound Med. 2011;30(11):1593–8.
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Abadía Barnó M, Marín Serrano E, Ruiz Fernández G. Use of abdominal ultrasound in the diagnosis of hepatic sinusoidal obstruction syndrome (SOS) in a patient receiving a hematopoietic-cell transplant. 4823/2017


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Publication history

Received: 02/01/2017

Accepted: 06/02/2017

Online First: 18/07/2017

Published: 31/07/2017

Article Online First time: 197 days

Article editing time: 210 days


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