Year 2019 / Volume 111 / Number 11
Original
The effect of Salvia miltiorrhiza in a mouse model of hepatic sinusoidal obstruction syndrome induced by Gynura segetum

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DOI: 10.17235/reed.2019.6085/2018

Li Yang, Ji-Rong Huo, Hong-Yi Zhu, Zhe Chen, Xiang-Yang Wang,

Abstract
Background and aims: to investigate the potential effect and mechanism of Salvia miltiorrhiza in Gynura segetum-induced hepatic sinusoidal obstruction syndrome (HSOS). Methods: the mice were gavaged with PBS, Gynura segetum or Gynura segetum, along with 100 or 200 mg/kg Salvia miltiorrhiza. Histological scoring and liver function were performed. The expression of tumor necrosis factor-alpha (TNF-α), vascular cellular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and nuclear transcription factor P65 (NF-κBp65) were determined by reverse transcriptase polymerase chain reaction (RT-PCR) and western blot. Results: liver function were effectively improved in the Salvia miltiorrhiza groups. The levels of TNF-α, VCAM-1, ICAM-1 and NF-κBp65 were significantly lower in the Salvia miltiorrhiza groups than in the Gynura segetum group. Conclusions: Salvia miltiorrhiza has a therapeutic effect on Gynura segetum-induced HSOS.
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Yang L, Huo J, Zhu H, Chen Z, Wang X. The effect of Salvia miltiorrhiza in a mouse model of hepatic sinusoidal obstruction syndrome induced by Gynura segetum. 6085/2018


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Publication history

Received: 01/12/2018

Accepted: 17/04/2019

Online First: 30/09/2019

Published: 07/11/2019

Article revision time: 126 days

Article Online First time: 303 days

Article editing time: 341 days


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