Year 2017 / Volume 109 / Number 8
Case Report
Intraductal papillary neoplasia of the bile duct with malignancy: a differentiated entity of cholangiocarcinoma with a better prognosis. A review of three new cases

592-595

DOI: 10.17235/reed.2017.4835/2016

Baltasar Pérez Saborido, Martín Bailón Cuadrado, Mario Rodríguez López, Enrique Asensio Díaz, Beatriz Madrigal Rubiales, Asterio Barrera Rebollo,

Abstract
Introduction: Intraductal papillary neoplasms of the bile duct have been recognized as a differentiated entity to other biliary tumors since 2001. They are characterized by intraductal growth, with or without mucus production, and have malignant potential, although they have a better prognosis than other types of cholangiocarcinoma. Case reports: From January 2010 to August 2015, we included three patients with a confirmed diagnosis of bile duct intraductal papillary neoplasia with malignancy that were treated at our center. Two cases were male and one female with a mean age of 67.3 years. All three patients presented malignancy at the time of diagnosis. One patient was asymptomatic and the diagnosis was reported in the hepatectomy specimen after a liver transplant due to autoimmune hepatitis. The other two patients presented with cholestasis and acute cholangitis and the diagnosis was made based on imaging tests (computed tomography [CT] and magnetic resonance imaging [MRI]) and endoscopic retrograde cholangiopancreatography (ERCP) with brushing and a biopsy. The treatment in both cases was surgical with a left hepatectomy, and resection of the left bile duct and segment I. They did not receive adjuvant treatment. None of the cases had recurrence of the disease. Discussion: Malignant intraductal papillary neoplasias of the biliary tract represent a different entity of cholangiocarcinoma with a better prognosis. Its diagnosis is based on imaging tests and histology by ERCP. The treatment is surgical, achieving a high rate of success with a low relapse rate.
Share Button
New comment
Comments
No comments for this article
References
1. Chen TC, Nakanuma Y, Zen Y et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology. 2001;34:651–8.
2. Fujikura K, Fukumoto T, Ajiki T et al. Comparative clinicopathological study of biliary intraductal papillary neoplasms and papillary cholangiocarcinomas. Histopathology. 2016;69:950–61.
3. Schlitter AM, Born D, Bettstetter M et al. Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways. Mod Pathol [Internet]. 2014;27:73–86.
4. Barton JG, Barrett D, Maricevich M et al. Intraductal papillary mucinous neoplasm of the biliary tract: a real disease? HPB (Oxford). 2009;11:684–91.
5. Nakanuma Y, Sato Y, Harada K et al. Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol. 2010;2:419–27.
6. Ohtsuka M, Kimura F, Shimizu H et al. Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion. Am J Surg Pathol. 2011;35:512–21.
7. Rocha FG, Lee H, Katabi N, et al. Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? Hepatology. 2012;56:1352–60.
8. Minagawa N, Sato N, Mori Y et al. A comparison between intraductal papillary neoplasms of the biliary tract (BT-IPMNs) and intraductal papillary mucinous neoplasms of the pancreas (P-IPMNs) reveals distinct clinical manifestations and outcomes. Eur J Surg Oncol; 2013;39:554–8.
9. Wan XS, Xu YY, Qian JY et al. Intraductal papillary neoplasm of the bile duct. World J Gastroenterol. 2013;19:8595–604.
10. Lee SS, Kim MH, Lee SK et al. Clinicopathologic Review of 58 Patients with Biliary Papillomatosis. Cancer. 2004;100:783–93.
11. Choi SC, Lee JK, Jung JH et al. The clinicopathological features of biliary intraductal papillary neoplasms according to the location of tumors. J Gastroenterol Hepatol. 2010;25:725–30.
12. Charre L, Boillot O, Goffette P et al. Long-term survival after isolated liver transplantation for intrahepatic biliary papillomatosis. Transpl Int. 2006;19:249–52.
Related articles

Digestive Diseases Image

Malignancy of intraductal papillary neoplasm of the bile duct

DOI: 10.17235/reed.2021.8193/2021

Letter to the Editor

Sternal cutaneous metastasis of hilar cholangiocarcinoma

DOI: 10.17235/reed.2017.4979/2017

Letter to the Editor

Lupus as a paraneoplastic manifestation of cholangiocarcinoma

DOI: 10.17235/reed.2016.4064/2015

Citation tools
Pérez Saborido B, Bailón Cuadrado M, Rodríguez López M, Asensio Díaz E, Madrigal Rubiales B, Barrera Rebollo A, et all. Intraductal papillary neoplasia of the bile duct with malignancy: a differentiated entity of cholangiocarcinoma with a better prognosis. A review of three new cases. 4835/2016


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 323 visits.
This article has been downloaded 255 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 09/01/2017

Accepted: 03/04/2017

Online First: 15/06/2017

Published: 31/07/2017

Article revision time: 81 days

Article Online First time: 157 days

Article editing time: 203 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology