Year 2017 / Volume 109 / Number 12
Letter to the Editor
Chemoprevention of polyp recurrence with curcumin followed by silibinin in a case of multiple colorectal adenomas

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DOI: 10.17235/reed.2017.5178/2017

Vicente Alfonso-Moreno, Antonio López-Serrano, Eduardo Moreno-Osset,

Abstract
Chemoprevention is a practical approach to reduce the risk of various cancers including colorectal cancer (CRC). The goal is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent its progression to CRC. Curcumin and silibinin prevent intestinal polyp formation in mice. Curcumin sensitizes silymarin to exert synergistic anticancer activity in colon cancer cells. Patients presenting with multiple colorectal adenomatous polyps (MCRA) have a high lifetime risk for CRC. We present a 57-year-old man with MCRA, without deleterious germline APC or MYH mutations. Our patient had 54 polyps in the first colonoscopy, most of 3 to 8 mm and one of 20 mm with high grade dysplasia / adenocarcinoma. Four subsequent colonoscopies showed continuous development of adenomatous polyps treated by polypectomy for the most part and some with heat. After the treatment with curcumin for 3 months and a half followed by silibinin for 9 months, we find many less polyps than in the previous colonoscopies, going from the finding of 40 adenomas of 3-6 mm in the pre-treatment colonoscopy to 3 polyps after treatment.
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References
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Alfonso-Moreno V, López-Serrano A, Moreno-Osset E. Chemoprevention of polyp recurrence with curcumin followed by silibinin in a case of multiple colorectal adenomas. 5178/2017


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Publication history

Received: 18/07/2017

Accepted: 25/07/2017

Online First: 23/10/2017

Published: 04/12/2017

Article Online First time: 97 days

Article editing time: 139 days


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