Year 2023 / Volume 115 / Number 4
Letter
A gastric neuroendocrine tumor after prolonged use of proton pump inhibitors

209-210

DOI: 10.17235/reed.2022.9126/2022

Pedro Henrique Teles Prado, Rosival Vicente de Paula, Andressa Tomé Rezende de Faria, Bruna Lemos Silva, Jose Celso Ardengh,

Abstract
We describe a case of a gastric neuroendocrine tumor (NET) in a patient with a history of long- term proton pump inhibitor (PPI) use. A 29- year- old man using PPI for the last 10 years due to gastroesophageal reflux disease developed progressive bouts of heartburn. Upper gastrointestinal endoscopy localized an elevated lesion with central depression in the greater curvature of gastric body. Lesion biopsies revealed a well- differentiated neuroendocrine tumor. Despite PPIs have a well- established safety profile, concerns have been raised about a potential relationship between PPI- induced hypergastrinemia and the development of neuroendocrine tumors.
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References
1. Gluckman CR, Metz DC. Gastric Neuroendocrine Tumors (Carcinoids). Curr Gastroenterol Rep. 2019 Mar 12;21(4):13. doi: 10.1007/s11894-019-0684-7. PMID: 30868284.
2. Kim JY, Hong SM, Ro JY. Recent updates on grading and classification of neuroendocrine tumors. Ann Diagn Pathol. 2017 Aug;29:11-16.
3. Sato Y, Hashimoto S, Mizuno K, Takeuchi M, Terai S. Management of gastric and duodenal neuroendocrine tumors. World J Gastroenterol. 2016 Aug 14;22(30):6817-28.
4. Furukawa K, Nakamura M, Kawashima H, Fujishiro M. Endoscopic resection of a duodenal neuroendocrine tumor. Rev Esp Enferm Dig. 2022;114(5):291-292. doi:10.17235/reed.2021.8232/2021
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Prado P, Paula R, de Faria A, Silva B, Ardengh J. A gastric neuroendocrine tumor after prolonged use of proton pump inhibitors. 9126/2022


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Publication history

Received: 10/08/2022

Accepted: 13/09/2022

Online First: 23/09/2022

Published: 03/04/2023

Article Online First time: 44 days

Article editing time: 236 days


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