Year 2020 / Volume 112 / Number 10
Review
New celiac disease biomarkers

792-796

DOI: 10.17235/reed.2020.7217/2020

Laura Rodríguez-Martín, Luis Vaquero, Santiago Vivas,

Abstract
Advances in the knowledge regarding celiac disease have enabled the development of diagnostic markers, such as anti-tissue transglutaminase and anti-deaminated gliadin antibodies. The wide availability of these antibodies, genetic studies of HLA-DQ and duodenal biopsies constitute the pillars necessary for a definitive diagnosis. However, difficulties sometimes arise in both the diagnosis and follow-up of celiac patients, which cannot be resolved using these tools. This article reviews the scientific evidence and possible clinical utility of different biomarkers. This review is structured according to biomarkers that have been evaluated pathophysiologically in relation to intestinal damage or immune response and their potential clinical utility in the diagnosis and follow-up of celiac disease patients.
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24/07/2024 16:49:21
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References
[1] Rubin JE, Crowe SE. Celiac disease. Ann Intern Med 2020;172:ITC1–16. https://doi.org/10.7326/AITC202001070.
[2] Burgueño Gómez B, Escudero-Hernández C, Rodrigo de P, et al. Duodenal lymphogram as a complementary tool in the diagnosis of celiac disease in adults. Rev Esp Enf Dig 2020; https://doi.org/10.17235/reed.2020.6391/2019. Online ahead of print.
[3] Sadeghi A, Rad N, Ashtari S, et al. The value of a biopsy in celiac disease follow up: Assessment of the small bowel after 6 and 24 months treatment with a gluten free diet. Rev Esp Enf Dig 2020; 112:101-108. https://doi.org/10.17235/reed.2019.5947/2018.
[4] Strimbu K, Tavel JA. What are biomarkers? Curr Opin HIV AIDS 2010;5:463–6. https://doi.org/10.1097/COH.0b013e32833ed177.
[5] Yu XB, Uhde M, Green PH, et al. Autoantibodies in the extraintestinal manifestations of celiac disease. Nutrients 2018;10. https://doi.org/10.3390/nu10081123.
[6] Choung RS, Khaleghi Rostamkolaei S, Ju JM, et al. Synthetic Neoepitopes of the Transglutaminase–Deamidated Gliadin Complex as Biomarkers for Diagnosing and Monitoring Celiac Disease. Gastroenterology 2019;156:582-591.e1. https://doi.org/10.1053/j.gastro.2018.10.025.
[7] Picascia S, Mandile R, Auricchio R, et al. Gliadin-Specific T-cells mobilized in the peripheral blood of coeliac patients by short oral gluten challenge: Clinical applications. Nutrients 2015;7:10020–31. https://doi.org/10.3390/nu7125515.
[8] Adriaanse M, Leffler DA. Serum markers in the clinical management of celiac disease. Dig Dis 2015;33:236–43. https://doi.org/10.1159/000371405.
[9] Adriaanse MPM, Tack GJ, Passos VL, et al. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies. Aliment Pharmacol Ther 2013;37:482–90. https://doi.org/10.1111/apt.12194.
[10] Vreugdenhil AC, Wolters VM, Adriaanse MP, et al. Additional value of serum I-FABP levels for evaluating celiac disease activity in children. Scand J Gastroenterol 2011;46:1435–41. https://doi.org/10.3109/00365521.2011.627447.
[11] Adriaanse MPM, Leffler DA, Kelly CP, et al. Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge. Am J Gastroenterol 2016;111:1014–22. https://doi.org/10.1038/ajg.2016.162.
[12] Rodríguez-Martín L, Vaquero L, Vivas S. Serum I-FABP as marker for enterocyte damage in first-degree relatives of patients with coeliac disease. Aliment Pharmacol Ther 2015;42:121–2. https://doi.org/10.1111/apt.13187.
[13] Singh A, Pramanik A, Acharya P, et al. Non-Invasive Biomarkers for Celiac Disease. J Clin Med 2019;8:885. https://doi.org/10.3390/jcm8060885.
[14] Fragkos KC, Forbes A. Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis. United European Gastroenterol J 2018;6:181–91. https://doi.org/10.1177/2050640617737632.
[15] Singh A, Verma AK, Das P, et al. Non-immunological biomarkers for assessment of villous abnormalities in patients with celiac disease. J Gastroenterol Hepatol 2020;35:438–45. https://doi.org/10.1111/jgh.14852.
[16] Morón B, Verma AK, Das P, et al. CYP3A4-catalyzed simvastatin metabolism as a non-invasive marker of small intestinal health in celiac disease. Am J Gastroenterol 2013;108:1344–51. https://doi.org/10.1038/ajg.2013.151.
[17] Manti S, Cuppari C, Tardino L, et al. HMGB1 as a new biomarker of celiac disease in children: A multicenter study. Nutrition 2017;37:18–21. https://doi.org/10.1016/j.nut.2016.12.011.
[18] Palone F, Vitali R, Trovato CM, et al. Faecal high mobility group box 1 in children with celiac disease: A pilot study. Dig Liv Dis 2018;50:916–9. https://doi.org/10.1016/j.dld.2018.04.003.
[19] Rashidiani S, Jalili A, Babaei E, et al. The chemokine CCL28 is elevated in the serum of patients with celiac disease and decreased after treatment. Am J Clin Exp Immunol 2017;6:60-65.
[20] López-Casado MA, Lorite P, Palomeque T, et al. Potential role of the IL-33/ST2 axis in celiac disease. Cell Mol Immunol 2017;14:285-292.https://doi.org/10.1038/cmi.2015.85.
[21] Pallone F, Monteleone Franzè G, et al. Characterization of IL-17A–Producing Cells in Celiac Disease Mucosa. J Immunol 2010;184:2211–8. https://doi.org/10.4049/jimmunol.0901919.
[22] Yuksel M, Kaplan M, Ates I, et al. The role of soluble tumor necrosis factor like weak inducer of apoptosis and interleukin-17A in the etiopathogenesis of celiac disease. Medicine (Baltimore) 2016;95:e3937. https://doi.org/10.1097/MD.0000000000003937.
[23] Comino I, Real A, Vivas S, et al. Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces. Am J Clin Nutr 2012;95:670–7. https://doi.org/10.3945/ajcn.111.026708.
[24] Moreno ML, Cebolla A, Muñoz-Suano A, et al. Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing. Gut 2017;66:250–7. https://doi.org/10.1136/gutjnl-2015-310148.
[25] Comino I, Fernández-Bañares F, Esteve M, et al. Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients. Am J Gastroenterol 2016;111:1456–65. https://doi.org/10.1038/ajg.2016.439.
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Rodríguez-Martín L, Vaquero L, Vivas S. New celiac disease biomarkers . 7217/2020


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Publication history

Received: 04/05/2020

Accepted: 26/05/2020

Online First: 21/09/2020

Published: 07/10/2020

Article revision time: 17 days

Article Online First time: 140 days

Article editing time: 156 days


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