Year 2024 / Volume 116 / Number 8
Letter
Coincidental oral lesions in Crohn’s disease

457-459

DOI: 10.17235/reed.2023.9992/2023

Lifeng Zhou, Li Wei, Xiaoguang Guo, Qiongxian Long, Huawei Ming,

Abstract
A 21-year-old patient with Crohn's disease, who was undergoing Infliximab treatment, presented at the hospital due to a painful oral mass. After confirming the absence of malignant cells through frozen sections, a complete excision of the infiltrated bone surrounding the lesion was performed. The postoperative pathology confirmed the presence of Central type giant cell granuloma in the mandible, which is distinct from non-caseating granulomas in oral CD and Infliximab-induced Sarcoidosis. As far as we are aware, this is the first to report an association between CGCG and both CD and anti-tumor necrosis factor therapy treatment.
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References
[1] Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones[J]. Oral Surg Oral Med Oral Pathol, 1953, 6(1): 159-175.
[2] Papanicolaou P, Chrysomali E, Stylogianni E, et al. Increased TNF-α, IL-6 and decreased IL-1β immunohistochemical expression by the stromal spindle-shaped cells in the central giant cell granuloma of the jaws. Med Oral Patol Oral Cir Bucal. 2012 Jan 1;17(1):e56-62.
[3] Cantanhede ALC, Olate S, de Assis AF, et al. Central Giant Cell Granuloma in the Mandibular Condyle in a Teenager. A Case Report with Literature Review. J Clin Med. 2022 Jul 21;11(14):4239.
[4] Shrestha S, Zhang J, Yan J, et al. Radiological features of central giant cell granuloma: comparative study of 7 cases and literature review. Dentomaxillofac Radiol. 2021 Jul 1;50(5):20200429.
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Zhou L, Wei L, Guo X, Long Q, Ming H. Coincidental oral lesions in Crohn’s disease. 9992/2023


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Publication history

Received: 02/10/2023

Accepted: 10/10/2023

Online First: 26/10/2023

Published: 01/08/2024

Article Online First time: 24 days

Article editing time: 304 days


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