Year 2003 / Volume 95 / Number 2
Notas
Whipple’s disease: report of cases diagnoses in our hospital

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C. Reyes Martínez, C. Cordero Fernández, R. Torronteras Santiago, F. R. Reina Campos,J. L. Márquez Galán y M. Sánchez Agüera

Abstract
We present here a retrospective study of nine patients diagnosed with Whipple's disease (WD) in our hospital. This report emphasises clinical presentation, diagnostic methods, treatment and
response to treatment.
In our study, the disease was more frequent in males, and the most frequent presenting symptoms were arthralgia, diarrhoea
and weight loss. Since the intestine is almost always affected, oral endoscopy is a useful technique for the diagnosis of WD because it
shows the typical miliary pattern and aids in obtaining biopsies to show the presence of PAS-positive macrophages (a suggestive though not diagnostic finding), to show bacilli using electron microscopy, or to detect genetic material using PCR.
Our patients responded well to treatment. The most frequently used antibiotic was oral trimethoprim-sulfamethoxazole for at least
one year. Treatment with penicillin G and IM streptomycin for 14 days was reserved for severe cases or cases that responded poorly to treatment.
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C. Reyes Martínez, C. Cordero Fernández, R. Torronteras Santiago, F. R. Reina Campos,J. L. Márquez Galán y M. Sánchez Agüera. Whipple’s disease: report of cases diagnoses in our hospital . 0


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