Year 2018 / Volume 110 / Number 6
Editorial
Lung transplantation and esophageal dysfunction

339-341

DOI: 10.17235/reed.2018.5693/2018

Antonio Ruiz de León San Juan,

Abstract
Lung transplants belong in the group of organ transplants with poorer outcomes, with acute rejection and bronchiolitis obliterans being cited as major causes of this. Poor allograft evolution has been associated with multiple factors, including those related to esophagogastric disease. In patients with end-stage pulmonary conditions eligible for a lung transplant gastroesophageal reflux (GER), esophageal dysmotily, and gastroparesis are highly prevalent and worsen upon transplantation, which may compromise transplant viability. High-resolution impedance manometry and long-term impedance pH-metry studies provide a new perspective where reflux and dysmotility share the limelight with changes in the diagnostic approach and in potential therapies.
Share Button
New comment
Comments
No comments for this article
References
1) Almeida Fortunato G, Mota Machado M, Feijó Andrade C, Felicetti JC, Peixoto Camargo JJ, Guerreiro Cardoso PF. Prevalence of gastroesophageal reflux in lung transplant candidates with advanced lung disease. J Bras Pneumol. 2008;34(10):772-778.
2) Boehlera A, Estenneb M. Bronquiolitis obliterante posterior al trasplante. Eur Respir J (edición española) 2004; 5(2): 106-19.
3) Pacheco-Galván A, Hart SP, Morice AH. La relación entre el reflujo gastroesofágico y las enfermedades de la vía aérea: el paradigma del reflujo a vía aérea. Arch Bronconeumol. 2011;47(4):195–203.
4) Ruiz de León San Juan A, Pérez de la Serna y Bueno JA, Sánchez Sánchez ML, Díaz-Rubio M. Bronconeumopatía crónica y actividad motora esofágica. Cirugía Española 1987, 41; monográfico, 240-246.
5) Sweet MP, Herbella FA, Leard L, Hoopes C, Golden J, Hays S, et al. The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantation. Ann Surg. 2006;244(4):491-7.
6) Khan MQ, Nizami IY, Khan BJ, Ashgar HIA. Lung Transplantation Triggered "Jackhammer Esophagus": A Case Report and Review of Literature. J Neurogastroenterol Motil 2013;19:390-394. https://doi.org/10.5056/jnm.2013.19.3.390.
7) Basseri B, Conklin JL, Pimentel M, et al. Esophageal motor dysfunction and gastroesophageal reflux are prevalent in lung transplant candidates. Ann Thorac Surg 2010;90: 1630-1636.
8) Raviv Y, D’Ovidio F, Pierre A, et al. Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes. Clin Transplant 2012;26: 133-142.
9) Akiyama J, Pasricha PJ, Weill D, Dhillon G, Sista R, Nguyen LAB. Esophageal Dysmotility After Lung Transplantation Assessed by High-Resolution Manometry. Gastroenterology 2011; 140 (5), Supplement 1, S-303.
10) Ruiz de León San Juan A, Sevilla Mantilla C, Pérez de la Serna JA, Díaz-Rubio M. Comportamiento pH-métrico de pacientes con esofagitis erosiva grave y en enfermedad por reflujo asociada a síntomas respiratorios Rev Esp Enferm Dig 2004; 96(Supl. I): O-21. 13.
11) Vaquero Barrios JM, Redel Montero J, Santos Luna F. Comorbilidades con impacto pronóstico tras el trasplante pulmonar. Arch Bronconeumol. 2014;50(1):25–33.
12) Castor JM, Wood RK, Muir AJ, Palmer SM, Shimpi RA. Gastroesophageal Reflux and Altered Motility in Lung Transplant Rejection. Neurogastroenterol Motil. 2010; 22(8): 841–850. doi:10.1111/j.1365-2982.2010.01522.x.
13) Hadjiliadis D, Duane Davis R, Steele MP et al. Gastroesophageal reflux disease in lung transplant recipients. Clin Transplant 2003; 17: 363–368
14) Kobeissy AA, Saeed A, Alaradi O. Esophageal Dysmotility as a Major Causative Factor for Reflux in Lung Transplant Candidates. Gastroenterology 2011; 140, (5), Supplement 1, S-256.
15) Lien D, Weinkauf J, Kapasi A, Fenton M, Helmersen D, Thakrar M, Wong J, Lazarescu A, Jackson K. Esophageal Motility and Impedance-pH in Lung Transplant Recipients. Abstracts. The Journal of Heart and Lung Transplantation, 2014; 32, (4S), 809, S293; S294.
16) Tangaroonsanti A, Lee AS, Crowell MD, et al. Impaired esophageal motility and clearance post-lung transplant: risk for chronic allograft failure. Clin Transl Gastroenterol 2017;8(6):e102. DOI: 10.1038/ctg.2017.30
17) Fortunato GA, Machado MM, Andrade CF, Felicetti JC, Camargo JJP, Cardoso PFG. Prevalence of gastroesophageal reflux in lung transplant candidates with advanced lung disease. J Bras Pneumol. 2008;34(10):772-778.
18) Ciriza-de-los-Ríos C, Canga-Rodríguez-Valcárcel F, De Pablos Gafas A, Castel-de-Lucas I, Lora-Pablos D, Castellano Tortajada G. Esophageal motor disorders are frequent during pre and post lung transplantation. Can they influence lung rejection?. Rev Esp Enferm Dig. 2018;
19) Fouad YM, et al. Ineffective esophageal motility: the most common motility abnormality in patients with GERD-associated respiratory symptoms. Am J Gastroenterol. 1999; 94(6):1464–1467.
20) Aggarwal P, Bansal V, Aggarwal N, Arora Z, Murthy S, Gabbard S. The case of self-resolving type III achalasia after bilateral lung transplant. Neurogastroenterol Motil. 2017;29:e13048.
Related articles

Digestive Diseases Image

Black esophagus

DOI: 10.17235/reed.2022.9217/2022

Case Report

Peroral endoscopic myotomy in pediatric jackhammer esophagus

DOI: 10.17235/reed.2018.5090/2017

Original

Colonic diverticulosis and the metabolic syndrome: an association?

DOI: 10.17235/reed.2017.5009/2017

Review

Impaired esophageal motor function in eosinophilic esophagitis

DOI: 10.17235/reed.2015.3801/2015

Citation tools
Ruiz de León San Juan A. Lung transplantation and esophageal dysfunction. 5693/2018


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1167 visits.
This article has been downloaded 267 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 03/05/2018

Accepted: 17/05/2018

Online First: 29/05/2018

Published: 31/05/2018

Article Online First time: 26 days

Article editing time: 28 days


Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology