Year 2016 / Volume 108 / Number 11
Digestive Diseases Image
Sprue-like enteropathy associated with olmesartan in a patient with villous atrophy, HLA-DQ2 genotype and antinuclear antibodies

732-733

Isidro Machado, María Reolid, Fernando Martínez de Juan, Carmen Martínez Lapiedra, Fernanda Maia de Alcántara,

Abstract
We describe a new case of enteropathy with villous atrophy in a patient suffering from arterial hypertension treated with olmesartan. The molecular and serological studies showed anti-nuclear antibodies (ANA) and haplotype HLA-DQ2 positive, as well as negative results for anti-transglutaminase, anti-endomysium and anti-enterocytes antibodies. A duodenal villous atrophy was suspected by upper gastrointestinal endoscopy, which was confirmed by histopathology. The morphological picture was suggestive of sprue-like enteropathy with severe lymphoid infiltration and predominant T lymphoid cells.
Share Button
New comment
Comments
No comments for this article
References
1- Greywoode R, Braunstein ED, Arquelles-Grande C et al. Olmesartan, other antihypertensives, and chronic diarrhea among patients undergoing endoscopic procedures: a case control study. Mayo Clin Proc 2014; 89: 1239–43. doi: 10.1016/j.mayocp.2014.05.012.
2- Marthey L, Cadiot G, Seksik P et al. Olmesartan-associated enteropathy: results of a national survey. Aliment Pharmacol Ther. 2014;40:1103–9. doi: 10.1111/apt.12937.
3- Fiorucci G, Puxeddu E, Colella R et al. Severe spruelike enteropathy due to olmesartan. Rev Esp Enferm Dig 2014;106: 142-4.
4- Téllez Villajos L, Crespo Pérez L, Cano Ruiz A et al. Enteropatia por olmesartan. Med Clin (Barc). 2015;144:140-1. doi: 10.1016/j.medcli.2014.06.006.
5- Téllez Villajos L, Crespo Pérez L, Cano Ruiz A. Atrofia vellositaria sin enfermedad celiaca: inverted question mark un nuevo síndrome o más confusión? Med Clin (Barc). 2015;144:121-5. doi: 10.1016/j.medcli.2014.05.022.
6- Ianiro G, Bibbò S, Montalto M et al. Aliment Systematic review: Sprue-like enteropathy associated with olmesartan. Pharmacol Ther. 2014; 40:16–23. doi: 10.1111/apt.12780.
Related articles

Digestive Diseases Image

Terminal ileitis - When all factors come together

DOI: 10.17235/reed.2022.9072/2022

Digestive Diseases Image

Villous atrophy, an endoscopic and diagnostic challenge

DOI: 10.17235/reed.2021.8169/2021

Letter

Balanced by iron. Hereditary hemochromatosis and celiac disease

DOI: 10.17235/reed.2020.7269/2020

Letter

Acute hepatitis due to olmesartan: an uncommon entity

DOI: 10.17235/reed.2020.7236/2020

Review

New celiac disease biomarkers

DOI: 10.17235/reed.2020.7217/2020

Original

Chronic diarrhea due to autoimmune enteropathy

DOI: 10.17235/reed.2020.7218/2020

Letter to the Editor

Sprue-like enteropathy linked to olmesartan

DOI: 10.17235/reed.2016.4140/2015

Letter to the Editor

Sprue-like enteropathy due to olmesartan

DOI: 10.17235/reed.2015.3791/2015

Citation tools
Machado I, Reolid M, Martínez de Juan F, Martínez Lapiedra C, Maia de Alcántara F. Sprue-like enteropathy associated with olmesartan in a patient with villous atrophy, HLA-DQ2 genotype and antinuclear antibodies . 3991/2015


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 633 visits.
This article has been downloaded 124 times.
Publication history

Received: 01/09/2015

Accepted: 05/10/2015

Published: 02/11/2016

Article revision time: 33 days

Article editing time: 428 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology