Year 2023 / Volume 115 / Number 7
Letter
Recurrent abdominal pain as the only clinical manifestation of hereditary angioedema type II

392-393

DOI: 10.17235/reed.2022.9119/2022

Daniel Muíño-Domínguez, Lorena Carballo-Folgoso, Luis Martínez Camblor, Marta García Calonge, Maria Helena González Sánchez, Isabel Pérez-Martínez, Ruth de Francisco, Sabino Riestra,

Abstract
Recurrent abdominal pain is a common reason for consultation in Gastroenterology. The differential diagnosis includes hereditary angioedema (HAE), a rare disorder characterized by recurrent episodes of angioedema, without urticaria or pruritus, which most often affects the skin, but also mucosal tissues of the gastrointestinal tract, triggered by diverse factors such as infections, trauma, surgery, drugs, or stress. It is a disease with a difficult diagnosis due to its heterogeneous and transitory clinical features, so having a clinical suspicion in the appropriate context would allow the administration of a specific treatment and avoid unnecessary examinations. We present the case of a 19-year-old male followed-up for recurrent abdominal pain that, after numerous microbiological, endoscopic, and radiological examinations, complement tests were requested, obtaining low levels of C4 with increased levels of C1 inhibitor and reduced functional activity, being diagnosed with HAE type II.
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References
1. Roche O, Blanch A, Caballero T, et al. Hereditary angioedema due to C1 inhibitor deficiency: patient registry and approach to the prevalence in Spain. Ann Allergy Asthma Immunol 2005; 94:498.
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Muíño-Domínguez D, Carballo-Folgoso L, Martínez Camblor L, García Calonge M, González Sánchez M, Pérez-Martínez I, et all. Recurrent abdominal pain as the only clinical manifestation of hereditary angioedema type II. 9119/2022


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Publication history

Received: 04/08/2022

Accepted: 29/08/2022

Online First: 30/09/2022

Published: 06/07/2023

Article Online First time: 57 days

Article editing time: 336 days


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