Year 2004 / Volume 96 / Number 6
Case Report
Pyoderma gangrenosum associated with ulcerative colitis: response to infliximab

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A. López San Román, F. Bermejo, I. Aldanondo, E. Carrera, D. Boixeda and E. Muñoz Zato

Abstract
Pyoderma gangrenosum is an extraintestinal manifestation of inflammatory bowel disease that can be therapeutically troublesome.
We comment on the case of a patient with clinically inactive ulcerative colitis who progressively developed necrotic lesions on both tibial
aspects of his legs, which corresponded both clinically and histologically to pyoderma gangrenosum. Treatment with steroids and
azathioprine could not control this complication. A single dose of infliximab 5 mg/kg was given, achieving an impressive response of
the skin lesions followed by complete healing 3 months later. Infliximab can be useful in the management of refractory extraintestinal
manifestations of inflammatory bowel disease.
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A. López San Román, F. Bermejo, I. Aldanondo, E. Carrera, D. Boixeda and E. Muñoz Zato. Pyoderma gangrenosum associated with ulcerative colitis: response to infliximab. 0


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