Year 2024 / Volume 116 / Number 11
Letter
Primary hepatic undifferentiated pleomorphic sarcoma with recurrence and widespread metastasis

654-655

DOI: 10.17235/reed.2024.10215/2023

Huabo Sun, Bingchang Ge, Jun Li,

Abstract
A 59-year-old man was referred to us for evaluation of asymptomatic mass in the liver that had been detected on ultrasonography performed during a physical screening. He had no history of hepatitis, and was otherwise well. Tumor markers were normal, including alpha fetoprotein, carcinoembryonic antigen, neuron-specific enolase and cancer antigen 199. Abdominal CT showed a 5.0 cm diameter low density mass in the S6 segment of his liver, with mild peripheral enhancement. Abdominal MR demonstrated the mass with hypointensity on T1WI, inhomogeneous hyperintensity on fat-suppressed T2WI, and mild peripheral enhancement. Partial hepatectomy was performed and pathological examination indicated undiferentiated pleomorphic sarcoma, with immunohistochemical results as follows: Vimentin (+), CK (-), CD68 (+), INI-1 (+), Hepa (-), Gly-3 (-), Arg-1 (-), HMB45 (-), CAM5,2 (-), CD31 (-), CD34 (-), CK7 (-), CK19 (-),Desmin (-), SMA (+), EMA (-), S-100 (-), Ki67 (50%+). The patient underwent postoperative chemotherapy with karelizumab and gemcitabine. However, repeat MR 3 months later showed multiple nodules with rim-like enhancement around the surgical margin. Subsequent repeat CT 6 months later reveled marked progression of the lesions.
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References
1. Pellegrini JR, Russe-Russe JR, Higgins TW, Prasandhan S, Khan N. Undifferentiated Hepatic Sarcoma: A Rare Case. Cureus 2022;14:e25895.
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Sun H, Ge B, Li J. Primary hepatic undifferentiated pleomorphic sarcoma with recurrence and widespread metastasis. 10215/2023


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Publication history

Received: 27/12/2023

Accepted: 28/12/2023

Online First: 18/01/2024

Published: 11/11/2024

Article Online First time: 22 days

Article editing time: 320 days


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