Year 2017 / Volume 109 / Number 11
Editorial
Point of care testing for paediatric coeliac disease in the new ESPGHAN era

741-742

DOI: 10.17235/reed.2017.5337/2017

Michelle Shui Yee Lau, David S. Sanders,

Abstract
One of the challenges in coeliac disease is the significant under-diagnosis despite the increasing prevalence and international guidelines for serological screening in appropriate patient cohorts. Several point-of-care tests for coeliac disease have been developed over the past decade with the aim of improving case detection using rapid and convenient testing. Most point-of-care tests, such as Biocard, detect anti-tissue transglutaminase (tTG) IgA antibodies, whereas Simtomax uniquely detects anti-deamidated gliadin peptide (DGP) IgA/IgG antibodies. A recent head-to-head trial in adults comparing two tTG-based point-of-care tests (Biocard and Celiac Quick Test) and Simtomax found that Simtomax was superior to Biocard and Celiac Quick Test, with sensitivities of 92.7%, 72.2% and 77.8%, respectively.
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References
1. West J, Fleming KM, Tata LJ et al. Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study. Am J Gastroenterol 2014;109(5):757-68.
2. Mooney PD, Wong SH, Johnston AJ et al. Increased Detection of Celiac Disease With Measurement of Deamidated Gliadin Peptide Antibody Before Endoscopy. Clin Gastroenterol Hepatol 2015;13(7):1278-84.e1.
3. Giersiepen K, Lelgemann M, Stuhldreher N et al. Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report. J Pediatr Gastroenterol Nutr. 2012;54(2):229-41.
4. Polanco I, Koester Weber T, Martínez-Ojinaga E et al. Efficacy of a point-of-care test based on deamidated gliadin peptides for the detection of celiac disease in pediatric patients. Rev Esp Enferm Dig 2017;……..
5. Bienvenu F, Besson Duvanel C, Seignovert C et al. Evaluation of a point-of-care test based on deamidated gliadin peptides for celiac disease screening in a large pediatric population. Eur J Gastroenterol Hepatol. 2012;24(12):1418-23.
6. Bienvenu F, Anghel SI, Besson Duvanel C et al. Early diagnosis of celiac disease in IgA deficient children: contribution of a point-of-care test. BMC Gastroenterol. 2014;14:186.
7. Benkebil F, Combescure C, Anghel SI et al. Diagnostic accuracy of a new point-of-care screening assay for celiac disease. World J Gastroenterol. 2013;19(31):5111-7.
8. Hin H, Bird G, Fisher P et al. Coeliac disease in primary care: case finding study. BMJ. 1999;318(7177):164-7.
9. Sanders DS, Patel D, Stephenson TJ et al. A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol. 2003;15(4):407-13.
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Lau M, Sanders D. Point of care testing for paediatric coeliac disease in the new ESPGHAN era. 5337/2017


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Publication history

Received: 24/10/2017

Accepted: 26/10/2017

Online First: 30/10/2017

Published: 02/11/2017

Article Online First time: 6 days

Article editing time: 9 days


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