Year 2024 / Volume 116 / Number 8
Letter
Persistently elevated alkaline phosphatase without hepatopathy? Literature review

447-448

DOI: 10.17235/reed.2023.9972/2023

Flor M. Fernández-Gordón Sánchez, Celia Gómez Labrador, Daniel Riado Mínguez, Sandra Agudo Fernández, Carlos Castaño Milla,

Abstract
Elevated alkaline phosphatase (ALP) levels are found in multiple hepatobiliary diseases and in bone diseases. ALP can also originate in the intestine and placenta. Very few cases of persistent elevations of IALP or in the context of benign familial intestinal hyperphosphatasemia (BFIH) without underlying pathology have been reported in the literature. In the evaluation of elevated ALP, most patients will not require determination of its isoenzymes. However, it is important to be aware of this entity to avoid unnecessary additional studies and to establish the diagnosis of a persistent but benign biochemical abnormality.
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References
1 Verma J, Gorard DA. Persistently elevated alkaline phosphatase. BMJ Case Rep. 2012;2012:bcr2012006768. Published 2012 Aug 24. doi:10.1136/bcr-2012-006768
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Fernández-Gordón Sánchez F, Gómez Labrador C, Riado Mínguez D, Agudo Fernández S, Castaño Milla C. Persistently elevated alkaline phosphatase without hepatopathy? Literature review. 9972/2023


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Publication history

Received: 20/09/2023

Accepted: 25/09/2023

Online First: 26/10/2023

Published: 01/08/2024

Article Online First time: 36 days

Article editing time: 316 days


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