Year 2010 / Volume 102 / Number 10
Original
NOD2, CD14 and TLR4 mutations do not influence response to adalimumab in patients with Crohn’s disease: a preliminary report

pp. 591-595

M. Barreiro-de Acosta, S. Ouburg, S. A. Morré, J. B. A. Crusius, A. Lorenzo, J. Potel, A. Salvador Peña and J. E. Domínguez-Muñoz

Abstract
Introduction: adalimumab is a recombinant fully-human monoclonal immunoglobulin (IgG1) antibody utilized in the treatment of Crohn´s disease. Unfortunately no clinical or genetic markers
exist to predict response to anti-tumor necrosis factor-alpha (TNF) therapy. The aim of this study was to evaluate the association between selected genes involved in cytokine regulation and response
to adalimumab treatment in Crohn’s disease.

Methods: twenty-four patients with Crohn’s disease either naïve (n = 8) or had lost response or were unable to tolerate the chimeric anti-TNF antibody infliximab (n=16) were enrolled in the
study. Patients were genotyped for main polymorphisms in NOD2, CD14 and TLR4 genes. Response to adalimumab treatment was defined as a decrease of Crohn’s disease activity index
of at least 100 points or a closure of at least 50% of fistulas in case of fistulizing Crohn’s disease.

Results: overall, 75% of patients did respond to treatment.
However, no statistically significant association was found between any of the genotypes and the response to adalimumab.

Conclusions: in our small study group no association between the studied polymorphisms and response to adalimumab was apparent. Systematic studies to search for genetic markers of response to anti-TNF therapy are necessary.
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M. Barreiro-de Acosta, S. Ouburg, S. A. Morré, J. B. A. Crusius, A. Lorenzo, J. Potel, A. Salvador Peña and J. E. Domínguez-Muñoz. NOD2, CD14 and TLR4 mutations do not influence response to adalimumab in patients with Crohn’s disease: a preliminary report. 591-595


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