Year 2013 / Volume 105 / Number 3
Digestive Diseases Image
Gastric plasmablastic lymphoma in HIV-negative patient

pp. 166-167

Inês Marques, Ana Lagos and Beatriz Costa-Neves

Abstract
An 82-year-old female patient presented with melena, epi- gastric pain, progressive abdomen fullness and weight loss (8 kg) in the past 2 months. During physical examination, cutaneous pallor was evident and a large abdominal mass in epigastrium was palpable. There was no peripheric lym- phadenopathy or hepatosplenomegaly.
Blood count showed microcytic anemia and ferropenia (Hb = 7.5 g/dl, VGM = 79 fL; ferritin = 21 g/l, iron saturation = 23 %). Differential leukocyte counts, hepatic transaminase and lactate dehydrogenate levels were within normal limits.
Upper gastrointestinal endoscopy revealed large gastric body ulceration with areas of mucosal hyperemia and pallor (Fig. 1). Computed tomography of the abdomen (Fig. 2) showed diffuse wall thickening involving the gastric fundus, body and antrum.
Histological examination of the biopsy specimens revealed a diffuse, monomorphous proliferation of the tumour cells with features of immunoblasts, CD138, MUM-1, and kappa light chains positive (Fig. 3). These plasmablast-like features of tumour cells and lack of CD45 and B-cell associated antigens, disclosed the diagnosis of plasmablastic lymphoma (PBL).
Serology was negative for the human immunodeficiency virus (HIV), the electrophoretic pattern of serum proteins was normal and the bone marrow biopsy was free of lymphoma at histological evaluation.
The patient started treatment with CHOP (cyclophos- phamide, doxorubicin, vincristine, and prednisone) chemotherapy, but died before the second cycle was given.
Share Button
New comment
Comments
No comments for this article
Related articles
Citation tools
Inês Marques, Ana Lagos and Beatriz Costa-Neves. Gastric plasmablastic lymphoma in HIV-negative patient. 166-167


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 784 visits.
This article has been downloaded 11 times.
Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology