Year 2006 / Volume 98 / Number 7
Original
Extraintestinal manifestations of Crohn

pp. 510-517

A. Repiso, M. Alcántara, C. Muñoz-Rosas, R. Rodríguez-Merlo1, M. J. Pérez-Grueso, J. M. Carrobles and J. L. Martínez-Potenciano

Abstract
Background: patients with inflammatory bowel disease may suffer one or more extraintestinal manifestations during the course of their condition, these being more frequent in Crohn's
disease. The aim of our study was to evaluate the prevalence of extraintestinal manifestations in patients with Crohn's disease in our healthcare area, and to assess the relationship between its
presence and diverse clinical-evolutionary variables.

Material and methods: extraintestinal manifestations in 157 patients diagnosed with Crohn's disease in our center were retrospectively studied. The clinical-evolutionary characteristics of this
population were compared with respect to the presence or absence of different extraintestinal manifestations.

Results: sevent -two patients (46%) presented at least with one extraintestinal manifestation. Thirty-one percent were colitisrelated
manifestations (22% rheumatologic, 13% muco-cutaneous,
4% ophthalmologic), 11% cholelithiasis, 8% nephrolithiasis,
3% thromboembolic illness, and other manifestations were
less frequent. Fourteen percent presented with more than one extraintestinal
manifestation. Rheumatologic and muco-cutaneous
manifestations were significantly more frequent in patients with
disease confined to the colon. Cholelithiasis was significantly associated
to those over 40 and also to males. Nephrolithiasis was also
significantly associated to those over 40, and thromboembolic illness
was linked to females.
Conclusions: forty-six percent of patients with Crohn's disease
presented at least with one extraintestinal manifestation.
Thirty-one percent presented with colitis-related manifestations,
rheumatologic and muco-cutaneous manifestations being the most
frequent, whereas hepatic manifestations were infrequent.
Rheumatologic and muco-cutaneous manifestations were more
frequent in patients with disease confined to the colon.
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A. Repiso, M. Alcántara, C. Muñoz-Rosas, R. Rodríguez-Merlo1, M. J. Pérez-Grueso, J. M. Carrobles and J. L. Martínez-Potenciano. Extraintestinal manifestations of Crohn. 510-517


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