Year 2018 / Volume 110 / Number 9
Case Report
Effects of mesalazine enemas on lymphoid follicular proctitis

591-593

DOI: 10.17235/reed.2018.5481/2018

Zhipeng Liu, Silin Huang, Zhengyu Chen, Xinying Wang,

Abstract
Lymphoid follicular proctitis (LFP) is an uncommon inflammatory disease that is characterized by rectal bleeding, congested and granular mucosa without ulceration and abnormal and coalescing hyperplastic lymphoid follicles without acute inflammatory changes. The lesions are usually confined to the rectal mucosa. LFP therapy is not well defined. Herein, we present a case of LFP that was resolved with a rapid administration of mesalazine enemas. A 35-year-old male was admitted to our hospital due to intermittent rectal bleeding associated with stools. Total colonoscopy revealed nodular mucosa with top pinpoint-like ulcers from the rectum to the border between the sigmoid flexure and the rectum. The nodules congested together on the lower rectal segment and occupied 2/3 of the rectal lumina. Endoscopic submucosal dissection was performed in order to obtain more specimens for histologic examination, which revealed marked lymphoid follicular hyperplasia with prominent germinal centers and a conserved mantle zone. Treatment was started with mesalazine enemas of 4 g q.d. and the patient was asymptomatic after three days. All the lesions disappeared two months later. Mesalazine enemas could be a promising and effective therapeutic option for LFP therapy.
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References
1.Seo GS, Choi SC, Jo EY, et al. The usefulness of mesalazine suppositories for the treatment of lymphoid follicular proctitis. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2006;47:420-4
2.Shami VM, Waxman I. Lymphoid follicular proctitis mimicking rectal lymphoma: diagnosis by EMR. Gastrointestinal endoscopy 2004;60:648-52
3.Flejou JF, Potet F, Bogomoletz WV, et al. Lymphoid follicular proctitis. A condition different from ulcerative proctitis? Digestive diseases and sciences 1988;33:314-20
4.Toyoda H, Yamaguchi M, Uemura Y, et al. Successful treatment of lymphoid follicular proctitis with sulfasalazine suppositories. The American journal of gastroenterology 2000;95:2403-4
5.Ball CB. The Benign Neoplasms of the Rectum. British medical journal 1890;2:1353-5
6.Cornes JS, Wallace MH, Morson BC. Benign lymphomas of the rectum and anal canal: a study of 100 cases. The Journal of pathology and bacteriology 1961;82:371-82
7.Aozasa K, Ohsawa M, Soma T, et al. Malignant lymphoma of the rectum. Japanese journal of clinical oncology 1990;20:380-6
8.Bogomoletz WV, Flejou JF. Newly recognized forms of colitis: collagenous colitis, microscopic (lymphocytic) colitis, and lymphoid follicular proctitis. Seminars in diagnostic pathology 1991;8:178-89
9.Arai O, Iida T, Abe J, et al. Coexistence of lymphoid follicular proctitis and ulcerative colitis. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2013;110:1439-46
10.Gim S, Lee KN, Lee D, et al. Lymphoid follicular proctitis resembling rectal carcinoid tumor, confirmed by endoscopic resection. The Korean journal of internal medicine 2017;32:548-51
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Liu Z, Huang S, Chen Z, Wang X. Effects of mesalazine enemas on lymphoid follicular proctitis. 5481/2018


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Publication history

Received: 22/01/2018

Accepted: 09/05/2018

Online First: 22/06/2018

Published: 31/08/2018

Article revision time: 102 days

Article Online First time: 151 days

Article editing time: 221 days


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