Year 2021 / Volume 113 / Number 1
Letter
Bortezomib-induced acute pancreatitis, an uncommon adverse event

77

DOI: 10.17235/reed.2020.7120/2020

Eduardo Junquera Alonso, Lucía Seoane Blanco, Francisco Xavier Cano Calderero,

Abstract
Acute pancreatitis is one of the main reasons for hospitalization, with an increasing incidence and associated non-negligible morbidity and mortality. Its most common causes are alcohol and gallstones, and medications are a rare cause. The pathogenesis of acute drug pancreatitis is not yet known exactly and the diagnosis is based on the evident temporal relationship, having excluded the rest of the possible known causes of acute pancreatitis. We present the case of a 71-year-old patient diagnosed with IgG multiple myeloma treated with the Daratumumab, Bortezomib and Dexamethasone regimen. After Bortezomib administration, he developed epigastric pain and elevated pancreatic enzymes in the range of acute pancreatitis. After ruling out common causes, the diagnosis of acute pancreatitis caused by Bortezomib was reached, which presents a favorable rapid evolution after its elimination.
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References
Talamo G, Sivik J, Pandey MK, et al. Bortezomib-induced acute pancreatitis: Case report and review of the literature. J Oncol Pharm Pract. 2016 Apr;22(2):332-4.
Wang HH, Tsui J, Wang XY, et al. Bortezomib-induced acute pancreatitis in a patient with multiple myeloma. Leuk Lymphoma. 2014 Jun;55(6):1404-5.
Gupta H, Bansal R, Khanna S, et al. An unusual complication of bortezomib therapy: Acute pancreatitis. Indian J Nephrol. 2014 Mar;24(2):135-6.
García MC, Moreno A, Rosales JM, et al. Caso de pancreatitis aguda tóxica por infusiones de cola de caballo. Rev Esp Enferm Dig 2017;109(4):301-304.
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Junquera Alonso E, Seoane Blanco L, Cano Calderero F. Bortezomib-induced acute pancreatitis, an uncommon adverse event. 7120/2020


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Publication history

Received: 10/04/2020

Accepted: 15/04/2020

Online First: 19/11/2020

Published: 11/01/2021

Article Online First time: 223 days

Article editing time: 276 days


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