Year 2022 / Volume 114 / Number 1
Letter
Azathioprine-induced alopecia: a rare adverse event, early marker of myelotoxicity

63-64

DOI: 10.17235/reed.2021.8175/2021

Juan Antonio Vázquez Rodríguez, Esther Merino Gallego, Antonio José Baños Arévalo, Francisco Gallardo Sánchez, Leticia Miras Lucas, Álvaro Pérez González,

Abstract
Though not exempt from adverse events, azathioprine (AZA) is an inexpensive and effective drug in the induction and maintenance treatment of patients with inflammatory bowel disease. We present the case of a 20-year-old female patient with left-side ulcerative colitis in whom AZA was started at a dose of 1.5 mg/kg/day due to dependence on corticoids (thiopurine methyltransferase activity: 14.9 U/mL). Two weeks after starting treatment she began to report excessive hair loss, resulting in an almost complete loss of scalp hair.
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References
1. Luber RP, Honap S, Cunningham G, et al. Can We Predict the Toxicity and Response to Thiopurines in Inflammatory Bowel Diseases? Front Med (Lausanne). 2019;6:279.
2. Yang S-K, Hong M, Baek J, et al. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nat Genet. 2014 Sep;46(9):1017–20.
3. Kishibe M, Nozaki H, Fujii M, et al. Severe thiopurine-induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case-control study. J Dermatol. 2018 Oct;45(10):1160–5.
4. Nomura H, Kurihara Y, Saito M, et al. Azathioprine-induced alopecia and leukopenia associated with NUDT15 polymorphisms. J Eur Acad Dermatol Venereol. 2018 Oct;32(10):e386–9.
5. Bhokare AB. Azathioprine-induced alopecia as an early clinical marker of its myelotoxicity. Indian J Drugs Dermatol 2017;3:40-1.
Citation tools
Vázquez Rodríguez J, Merino Gallego E, Baños Arévalo A, Gallardo Sánchez F, Miras Lucas L, Pérez González Á, et all. Azathioprine-induced alopecia: a rare adverse event, early marker of myelotoxicity. 8175/2021


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Publication history

Received: 24/06/2021

Accepted: 23/08/2021

Online First: 14/09/2021

Published: 10/01/2022

Article revision time: 51 days

Article Online First time: 82 days

Article editing time: 200 days


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